Clinical impact of minimal residual disease in children with different subtypes of acute lymphoblastic leukemia treated with Response-Adapted therapy

To determine the clinical significance of minimal residual disease (MRD) in patients with prognostically relevant subtypes of childhood acute lymphoblastic leukemia (ALL), we analyzed data from 488 patients treated in St Jude Total Therapy Study XV with treatment intensity based mainly on MRD levels...

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Veröffentlicht in:	Leukemia 2017-02, Vol.31 (2), p.333-339
Hauptverfasser:	Pui, C-H, Pei, D, Raimondi, S C, Coustan-Smith, E, Jeha, S, Cheng, C, Bowman, W P, Sandlund, J T, Ribeiro, R C, Rubnitz, J E, Inaba, H, Gruber, T A, Leung, W H, Yang, J J, Downing, J R, Evans, W E, Relling, M V, Campana, D
Format:	Artikel
Sprache:	eng
Schlagworte:	692/308/2779/109 692/4028/67/1990/283/2125 692/699/1541/1990 692/699/67/1059 692/699/67/2332 Acute lymphoblastic leukemia Acute lymphocytic leukemia Adolescent Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bone marrow Cancer in children Cancer Research Care and treatment Child Child, Preschool Children Chromosomes Clinical outcomes Combined Modality Therapy Critical Care Medicine Diagnosis Female Health services Hematology Hematopoietic Stem Cell Transplantation Hospitals Humans Induction therapy Infant Intensive Internal Medicine Leukemia Leukocytes Lymphatic leukemia Lymphocytes T Male Medicine Medicine & Public Health Minimal residual disease Neoplasm, Residual - pathology Neoplasm, Residual - therapy Oncology original-article Patients Pediatrics Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy Prognosis Recurrence Remission Remission (Medicine) Remission Induction Risk Runx1 protein Survival Analysis Treatment Outcome
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