Beta protein 1 homeoprotein induces cell growth and estrogen-independent tumorigenesis by binding to the estrogen receptor in breast cancer

Expression of Beta Protein 1 (BP1), a homeotic transcription factor, increases during breast cancer progression and may be associated with tumor aggressiveness. In our present work, we investigate the influence of BP1 on breast tumor formation and size in vitro and in vivo. Cells overexpressing BP1...

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Veröffentlicht in:	Oncotarget 2016-08, Vol.7 (33), p.53204-53216
Hauptverfasser:	Fu, Sidney W, Kirolikar, Saurabh P, Ginsburg, Erika, Tan, Xiaohui, Schwartz, Arnold, Simmens, Samuel J, Man, Yan-Gao, Pinzone, Joseph J, Teal, Christine, Awate, Sanket, Vonderhaar, Barbara K, Berg, Patricia E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinogenesis - genetics Carcinogenesis - metabolism Cell Proliferation Estrogens - metabolism Female Gene Expression Regulation, Neoplastic Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans MCF-7 Cells Mice, Nude Protein Binding Receptors, Estrogen - genetics Receptors, Estrogen - metabolism Research Paper Transcription Factors - genetics Transcription Factors - metabolism Transplantation, Heterologous Tumor Burden - genetics
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