Overcoming HSP27-mediated resistance by altered dimerization of HSP27 using small molecules

Heat shock protein 27 (HSP27, HSPB1) is an anti-apoptotic protein characterized for its tumorigenic and metastatic properties, and now referenced as a major therapeutic target in many types of cancer. The biochemical properties of HSP27 rely on a structural oligomeric and dynamic organization that i...

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Veröffentlicht in:	Oncotarget 2016-08, Vol.7 (33), p.53178-53190
Hauptverfasser:	Kim, Jee Hye, Jung, Ye Jin, Choi, Byeol, Lee, Na Lim, Lee, Hae Jun, Kwak, Soo Yeon, Kwon, Youngjoo, Na, Younghwa, Lee, Yun-Sil
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - administration & dosage Antineoplastic Combined Chemotherapy Protocols - pharmacology Benzoquinones - administration & dosage Cell Line, Tumor Cell Survival - drug effects Cell Survival - genetics Cell Survival - radiation effects Chemoradiotherapy HSP27 Heat-Shock Proteins - antagonists & inhibitors HSP27 Heat-Shock Proteins - chemistry HSP27 Heat-Shock Proteins - genetics Humans Kaplan-Meier Estimate Lactams, Macrocyclic - administration & dosage Lung Neoplasms - metabolism Lung Neoplasms - pathology Lung Neoplasms - therapy Mice, Inbred BALB C Mice, Nude Protein Multimerization - drug effects Research Paper RNA Interference Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology Xanthones - administration & dosage Xanthones - chemistry Xanthones - pharmacology Xenograft Model Antitumor Assays
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