Agonistic analogs of growth hormone releasing hormone (GHRH) promote wound healing by stimulating the proliferation and survival of human dermal fibroblasts through ERK and AKT pathways

Decreased or impaired proliferation capability of dermal fibroblasts interferes with successful wound healing. Several growth factors tested failed to fully restore the growth of fibroblasts, possibly due to their rapid degradation by proteases. It is therefore critical to find new agents which have...

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Veröffentlicht in:	Oncotarget 2016-08, Vol.7 (33), p.52661-52672
Hauptverfasser:	Cui, Tengjiao, Jimenez, Joaquin J, Block, Norman L, Badiavas, Evangelos V, Rodriguez-Menocal, Luis, Vila Granda, Ailin, Cai, Renzhi, Sha, Wei, Zarandi, Marta, Perez, Roberto, Schally, Andrew V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Proliferation - drug effects Cell Survival - drug effects Cells, Cultured Dermis - cytology Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors Extracellular Signal-Regulated MAP Kinases - metabolism Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Flavonoids - pharmacology Growth Hormone-Releasing Hormone - agonists Humans Male Mice, Inbred C57BL Phosphorylation - drug effects Priority Research Paper: Pathology Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - metabolism Sermorelin - analogs & derivatives Sermorelin - pharmacology Signal Transduction - drug effects Wound Healing - drug effects
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