Platinum-containing compound platinum pyrithione is stronger and safer than cisplatin in cancer therapy

[Display omitted] DNA is the well-known molecular target of current platinum-based anticancer drugs; consequently, their clinical use is severely restricted by their systemic toxicities and drug resistance originating from non-selective DNA damage. Various strategies have been developed to circumven...

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Veröffentlicht in:	Biochemical pharmacology 2016-09, Vol.116, p.22-38
Hauptverfasser:	Zhao, Chong, Chen, Xin, Zang, Dan, Lan, Xiaoying, Liao, Siyan, Yang, Changshan, Zhang, Peiquan, Wu, Jinjie, Li, Xiaofen, Liu, Ningning, Liao, Yuning, Huang, Hongbiao, Shi, Xianping, Jiang, Lili, Liu, Xiuhua, He, Zhimin, Wang, Xuejun, Liu, Jinbao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - metabolism Adenocarcinoma - pathology Animals Antineoplastic Agents - adverse effects Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis - drug effects Cell Line Cells, Cultured Cisplatin - adverse effects Cisplatin - pharmacology Cisplatin - therapeutic use Deubiquitinases DNA damage Drug Resistance, Neoplasm Female Humans Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - pathology Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Lung Neoplasms - pathology Male Mice, Nude Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - metabolism Organoplatinum Compounds - adverse effects Organoplatinum Compounds - pharmacology Organoplatinum Compounds - therapeutic use Platinum pyrithione Proteasome Proteasome Inhibitors - adverse effects Proteasome Inhibitors - pharmacology Proteasome Inhibitors - therapeutic use Pyridines - adverse effects Pyridines - pharmacology Pyridines - therapeutic use Specific Pathogen-Free Organisms Tumor Tumor Burden - drug effects Ubiquitin Thiolesterase - antagonists & inhibitors Ubiquitin Thiolesterase - metabolism Xenograft Model Antitumor Assays
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