Neuroanatomical correlates of aging, cardiopulmonary fitness level, and education
Fitness and education may protect against cognitive impairments in aging. They may also counteract age‐related structural changes within the brain. Here we analyzed volumetric differences in cerebrospinal fluid and gray and white matter, along with neuropsychological data, in adults differing in age...
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| Veröffentlicht in: | Psychophysiology 2008-09, Vol.45 (5), p.825-838 |
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| creator | Gordon, Brian A. Rykhlevskaia, Elena I. Brumback, Carrie R. Lee, Yukyung Elavsky, Steriani Konopack, James F. McAuley, Edward Kramer, Arthur F. Colcombe, Stanley Gratton, Gabriele Fabiani, Monica |
| description | Fitness and education may protect against cognitive impairments in aging. They may also counteract age‐related structural changes within the brain. Here we analyzed volumetric differences in cerebrospinal fluid and gray and white matter, along with neuropsychological data, in adults differing in age, fitness, and education. Cognitive performance was correlated with fitness and education. Voxel‐based morphometry was used for a whole‐brain analysis of structural magnetic resonance images. We found age‐related losses in gray and white matter in medial‐temporal, parietal, and frontal areas. As in previous work, fitness within the old correlated with preserved gray matter in the same areas. In contrast, higher education predicted preserved white matter in inferior frontal areas. These data suggest that fitness and education may both be predictive of preserved cognitive function in aging through separable effects on brain structure. |
| doi_str_mv | 10.1111/j.1469-8986.2008.00676.x |
| format | Article |
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They may also counteract age‐related structural changes within the brain. Here we analyzed volumetric differences in cerebrospinal fluid and gray and white matter, along with neuropsychological data, in adults differing in age, fitness, and education. Cognitive performance was correlated with fitness and education. Voxel‐based morphometry was used for a whole‐brain analysis of structural magnetic resonance images. We found age‐related losses in gray and white matter in medial‐temporal, parietal, and frontal areas. As in previous work, fitness within the old correlated with preserved gray matter in the same areas. In contrast, higher education predicted preserved white matter in inferior frontal areas. These data suggest that fitness and education may both be predictive of preserved cognitive function in aging through separable effects on brain structure.</description><identifier>ISSN: 0048-5772</identifier><identifier>EISSN: 1469-8986</identifier><identifier>EISSN: 1540-5958</identifier><identifier>DOI: 10.1111/j.1469-8986.2008.00676.x</identifier><identifier>PMID: 18627534</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Aging ; Aging - physiology ; Brain ; Brain - anatomy & histology ; Brain - physiology ; Cardiovascular Physiological Phenomena ; Cerebrospinal fluid (CSF) ; Cognition & reasoning ; Dementia ; Education ; Female ; Fitness ; Grey matter ; Humans ; Magnetic Resonance Imaging ; Male ; Neuropsychological Tests ; Physical fitness ; Physical Fitness - physiology ; Physiological psychology ; Structural magnetic resonance imaging (MRI) ; Voxel-based morphometry (VBM) ; White matter</subject><ispartof>Psychophysiology, 2008-09, Vol.45 (5), p.825-838</ispartof><rights>Copyright © 2008 Society for Psychophysiological Research</rights><rights>Copyright © 2008 by the Society for Psychophysiological Research</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6346-124cd5504cdf253d399e985405f0b1d3947b72c2ab5f3115a2533599624c119d3</citedby><cites>FETCH-LOGICAL-c6346-124cd5504cdf253d399e985405f0b1d3947b72c2ab5f3115a2533599624c119d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1469-8986.2008.00676.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1469-8986.2008.00676.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18627534$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gordon, Brian A.</creatorcontrib><creatorcontrib>Rykhlevskaia, Elena I.</creatorcontrib><creatorcontrib>Brumback, Carrie R.</creatorcontrib><creatorcontrib>Lee, Yukyung</creatorcontrib><creatorcontrib>Elavsky, Steriani</creatorcontrib><creatorcontrib>Konopack, James F.</creatorcontrib><creatorcontrib>McAuley, Edward</creatorcontrib><creatorcontrib>Kramer, Arthur F.</creatorcontrib><creatorcontrib>Colcombe, Stanley</creatorcontrib><creatorcontrib>Gratton, Gabriele</creatorcontrib><creatorcontrib>Fabiani, Monica</creatorcontrib><title>Neuroanatomical correlates of aging, cardiopulmonary fitness level, and education</title><title>Psychophysiology</title><addtitle>Psychophysiology</addtitle><description>Fitness and education may protect against cognitive impairments in aging. They may also counteract age‐related structural changes within the brain. Here we analyzed volumetric differences in cerebrospinal fluid and gray and white matter, along with neuropsychological data, in adults differing in age, fitness, and education. Cognitive performance was correlated with fitness and education. Voxel‐based morphometry was used for a whole‐brain analysis of structural magnetic resonance images. We found age‐related losses in gray and white matter in medial‐temporal, parietal, and frontal areas. As in previous work, fitness within the old correlated with preserved gray matter in the same areas. In contrast, higher education predicted preserved white matter in inferior frontal areas. These data suggest that fitness and education may both be predictive of preserved cognitive function in aging through separable effects on brain structure.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Aging - physiology</subject><subject>Brain</subject><subject>Brain - anatomy & histology</subject><subject>Brain - physiology</subject><subject>Cardiovascular Physiological Phenomena</subject><subject>Cerebrospinal fluid (CSF)</subject><subject>Cognition & reasoning</subject><subject>Dementia</subject><subject>Education</subject><subject>Female</subject><subject>Fitness</subject><subject>Grey matter</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Neuropsychological Tests</subject><subject>Physical fitness</subject><subject>Physical Fitness - physiology</subject><subject>Physiological psychology</subject><subject>Structural magnetic resonance imaging (MRI)</subject><subject>Voxel-based morphometry (VBM)</subject><subject>White matter</subject><issn>0048-5772</issn><issn>1469-8986</issn><issn>1540-5958</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtvEzEUhS0EoiHwF9CIBavO4Mf4tQAJFRpAVSkChFhZjscTHDx2sGdK-u9xSBQeG_DCvtb9ztG1DwAVgg0q68m6QS2TtZCCNRhC0UDIOGu2t8Ds2LgNZhC2oqac4xNwL-c1hFAijO-CEyQY5pS0M_Du0k4p6qDHODijfWViStbr0eYq9pVeubA6rYxOnYubyQ8x6HRT9W4MNufK22vrTysdusp2k9Gji-E-uNNrn-2DwzkHH89ffjh7VV-8Xbw-e35RG0ZaViPcmo5SWPYeU9IRKa0UtIW0h0tUri1fcmywXtKeIER1gQiVkhUdQrIjc_Bs77uZloPtjA1j0l5tkhvKiCpqp_7sBPdFreK1oljwYl8MHh8MUvw22TyqwWVjvdfBxikrJqkguOX_BDGCWOxM5-DRX-A6TimUXygMKU4EogKJPWRSzDnZ_jgygmqXrlqrXYhqF6Lapat-pqu2Rfrw9yf_Eh7iLMDTPfDdeXvz38bq6v3nq1IVfb3Xuzza7VGv01fFOOFUfbpcqHNM-IvFm6ImPwD-ccJ4</recordid><startdate>200809</startdate><enddate>200809</enddate><creator>Gordon, Brian A.</creator><creator>Rykhlevskaia, Elena I.</creator><creator>Brumback, Carrie R.</creator><creator>Lee, Yukyung</creator><creator>Elavsky, Steriani</creator><creator>Konopack, James F.</creator><creator>McAuley, Edward</creator><creator>Kramer, Arthur F.</creator><creator>Colcombe, Stanley</creator><creator>Gratton, Gabriele</creator><creator>Fabiani, Monica</creator><general>Blackwell Publishing Inc</general><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200809</creationdate><title>Neuroanatomical correlates of aging, cardiopulmonary fitness level, and education</title><author>Gordon, Brian A. ; Rykhlevskaia, Elena I. ; Brumback, Carrie R. ; Lee, Yukyung ; Elavsky, Steriani ; Konopack, James F. ; McAuley, Edward ; Kramer, Arthur F. ; Colcombe, Stanley ; Gratton, Gabriele ; Fabiani, Monica</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6346-124cd5504cdf253d399e985405f0b1d3947b72c2ab5f3115a2533599624c119d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Aging - physiology</topic><topic>Brain</topic><topic>Brain - anatomy & histology</topic><topic>Brain - physiology</topic><topic>Cardiovascular Physiological Phenomena</topic><topic>Cerebrospinal fluid (CSF)</topic><topic>Cognition & reasoning</topic><topic>Dementia</topic><topic>Education</topic><topic>Female</topic><topic>Fitness</topic><topic>Grey matter</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Neuropsychological Tests</topic><topic>Physical fitness</topic><topic>Physical Fitness - physiology</topic><topic>Physiological psychology</topic><topic>Structural magnetic resonance imaging (MRI)</topic><topic>Voxel-based morphometry (VBM)</topic><topic>White matter</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gordon, Brian A.</creatorcontrib><creatorcontrib>Rykhlevskaia, Elena I.</creatorcontrib><creatorcontrib>Brumback, Carrie R.</creatorcontrib><creatorcontrib>Lee, Yukyung</creatorcontrib><creatorcontrib>Elavsky, Steriani</creatorcontrib><creatorcontrib>Konopack, James F.</creatorcontrib><creatorcontrib>McAuley, Edward</creatorcontrib><creatorcontrib>Kramer, Arthur F.</creatorcontrib><creatorcontrib>Colcombe, Stanley</creatorcontrib><creatorcontrib>Gratton, Gabriele</creatorcontrib><creatorcontrib>Fabiani, Monica</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Psychophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gordon, Brian A.</au><au>Rykhlevskaia, Elena I.</au><au>Brumback, Carrie R.</au><au>Lee, Yukyung</au><au>Elavsky, Steriani</au><au>Konopack, James F.</au><au>McAuley, Edward</au><au>Kramer, Arthur F.</au><au>Colcombe, Stanley</au><au>Gratton, Gabriele</au><au>Fabiani, Monica</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuroanatomical correlates of aging, cardiopulmonary fitness level, and education</atitle><jtitle>Psychophysiology</jtitle><addtitle>Psychophysiology</addtitle><date>2008-09</date><risdate>2008</risdate><volume>45</volume><issue>5</issue><spage>825</spage><epage>838</epage><pages>825-838</pages><issn>0048-5772</issn><eissn>1469-8986</eissn><eissn>1540-5958</eissn><abstract>Fitness and education may protect against cognitive impairments in aging. They may also counteract age‐related structural changes within the brain. Here we analyzed volumetric differences in cerebrospinal fluid and gray and white matter, along with neuropsychological data, in adults differing in age, fitness, and education. Cognitive performance was correlated with fitness and education. Voxel‐based morphometry was used for a whole‐brain analysis of structural magnetic resonance images. We found age‐related losses in gray and white matter in medial‐temporal, parietal, and frontal areas. As in previous work, fitness within the old correlated with preserved gray matter in the same areas. In contrast, higher education predicted preserved white matter in inferior frontal areas. These data suggest that fitness and education may both be predictive of preserved cognitive function in aging through separable effects on brain structure.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>18627534</pmid><doi>10.1111/j.1469-8986.2008.00676.x</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Psychophysiology, 2008-09, Vol.45 (5), p.825-838 |
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| subjects | Adult Aged Aged, 80 and over Aging Aging - physiology Brain Brain - anatomy & histology Brain - physiology Cardiovascular Physiological Phenomena Cerebrospinal fluid (CSF) Cognition & reasoning Dementia Education Female Fitness Grey matter Humans Magnetic Resonance Imaging Male Neuropsychological Tests Physical fitness Physical Fitness - physiology Physiological psychology Structural magnetic resonance imaging (MRI) Voxel-based morphometry (VBM) White matter |
| title | Neuroanatomical correlates of aging, cardiopulmonary fitness level, and education |
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