Putting PHDs to work: PHF11 clears the way for EXO1 in double-strand break repair
In this issue of Genes & Development, Gong and colleagues (pp. 46-58) bring to light a functional role for plant homeodomain finger 11 (PHF11) in 5' end resection at DNA double-strand breaks (DSBs). Using the proteomics of isolated chromatin segments (PICh) technique to purify deprotected t...
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| Veröffentlicht in: | Genes & development 2017-01, Vol.31 (1), p.3-5 |
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| creator | Zahn, Karl E Greenberg, Roger A |
| description | In this issue of Genes & Development, Gong and colleagues (pp. 46-58) bring to light a functional role for plant homeodomain finger 11 (PHF11) in 5' end resection at DNA double-strand breaks (DSBs). Using the proteomics of isolated chromatin segments (PICh) technique to purify deprotected telomeres, PHF11 was enriched as cells mounted a DNA damage response (DDR) against exposed chromosome ends. The study reveals interactions between PHF11 and multiple DNA repair proteins and suggests that PHF11 mediates 5' end resection by negotiating RPA-coated DNA repair intermediates. This finding provides a novel context for mediator-catalyzed RPA exchanges during the multistep process of homologous recombination (HR). |
| doi_str_mv | 10.1101/gad.295923.117 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | DNA Breaks, Double-Stranded DNA Repair DNA-Binding Proteins - genetics Exodeoxyribonucleases - genetics Homologous Recombination Outlook |
| title | Putting PHDs to work: PHF11 clears the way for EXO1 in double-strand break repair |
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