TDAG8 involved in initiating inflammatory hyperalgesia and establishing hyperalgesic priming in mice

Chronic pain, resulting from injury, arthritis, and cancer, is often accompanied by inflammation. High concentrations of protons found in inflamed tissues results in tissue acidosis, a major cause of pain and hyperalgesia. Acidosis signals may mediate a transition from acute to chronic hyperalgesia...

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Veröffentlicht in:	Scientific reports 2017-02, Vol.7 (1), p.41415, Article 41415
Hauptverfasser:	Dai, Shih-Ping, Huang, Ya-Han, Chang, Chung-Jen, Huang, Yu-Fen, Hsieh, Wei-Shan, Tabata, Yasuhiko, Ishii, Satoshii, Sun, Wei-Hsin
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 13/95 14/34 14/35 38 38/77 631/378/1959/2605 692/4017 Acidosis Animals Arthritis Bone cancer Calcium - metabolism Calcium Signaling Carrageenan Cell death Chronic pain Cyclic AMP - metabolism Freund's Adjuvant G protein-coupled receptors Gene Deletion Gene Knockdown Techniques HEK293 Cells Humanities and Social Sciences Humans Hydrogen-Ion Concentration Hyperalgesia Hyperalgesia - metabolism Hyperalgesia - pathology Inflammation Inflammation - metabolism Inflammation - pathology Intracellular Space - metabolism Lymphocytes T Mice, Inbred ICR multidisciplinary Pain Pain perception pH effects Protons Receptors, G-Protein-Coupled - agonists Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism RNA, Small Interfering - metabolism Rodents Science Science (multidisciplinary) Spinal cord
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