The E3 ubiquitin ligase RNF114 and TAB1 degradation are required for maternal‐to‐zygotic transition

The functional role of the ubiquitin‐proteasome pathway during maternal‐to‐zygotic transition (MZT) remains to be elucidated. Here we show that the E3 ubiquitin ligase, Rnf114, is highly expressed in mouse oocytes and that knockdown of Rnf114 inhibits development beyond the two‐cell stage. To study...

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Veröffentlicht in:	EMBO reports 2017-02, Vol.18 (2), p.205-216
Hauptverfasser:	Yang, Ye, Zhou, Cheng, Wang, Ying, Liu, Weixiao, Liu, Chao, Wang, Liying, Liu, Yujiao, Shang, Yongliang, Li, Mingrui, Zhou, Shuai, Wang, Yuanting, Zeng, Wentao, Zhou, Jianli, Huo, Ran, Li, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Cluster Analysis EMBO11 EMBO31 Embryonic Development - genetics Embryos Enzymes Female Gene Expression Profiling Gene Expression Regulation, Developmental Gene Knockdown Techniques Maternal Inheritance maternal‐to‐zygotic transition Mice NF-kappa B - metabolism NF‐κB pathway Oocytes - metabolism Polyubiquitin - metabolism Proteolysis RNF114 Rodents Scientific Report Scientific Reports Signal Transduction Substrate Specificity TAB1 two‐cell‐stage arrest Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Zygote - metabolism
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