Complex structure of cytochrome c–cytochrome c oxidase reveals a novel protein–protein interaction mode

Mitochondrial cytochrome c oxidase (C c O) transfers electrons from cytochrome c (Cyt. c ) to O 2 to generate H 2 O, a process coupled to proton pumping. To elucidate the mechanism of electron transfer, we determined the structure of the mammalian Cyt. c –C c O complex at 2.0‐Å resolution and identi...

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Veröffentlicht in:	The EMBO journal 2017-02, Vol.36 (3), p.291-300
Hauptverfasser:	Shimada, Satoru, Shinzawa‐Itoh, Kyoko, Baba, Junpei, Aoe, Shimpei, Shimada, Atsuhiro, Yamashita, Eiki, Kang, Jiyoung, Tateno, Masaru, Yoshikawa, Shinya, Tsukihara, Tomitake
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cattle Cellular biology Crystal structure Crystallography, X-Ray Cytochrome cytochrome c cytochrome c oxidase Cytochromes c - chemistry Cytochromes c - metabolism electron transfer complex Electron Transport Electron Transport Complex IV - chemistry Electron Transport Complex IV - metabolism EMBO20 EMBO21 EMBO40 Enzymes Horses Mammals Models, Biological Models, Molecular Molecular biology Oxygen - metabolism Protein Binding Protein Conformation Proteins protein–protein interaction Surface water Water - metabolism X‐ray crystallography
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