Stem cell mobilization is life saving in an animal model of acute liver failure

No therapy except liver transplantation currently exists for patients with acute liver failure (ALF). The aim of this study was to determine whether pharmacologic mobilization of endogenous hematopoietic stem cells (HSCs) can aid in liver repair and improve survival in an animal model of ALF. Rodent...

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Veröffentlicht in:	Annals of surgery 2010-10, Vol.252 (4), p.591-596
Hauptverfasser:	Mark, Anthony L, Sun, Zhaoli, Warren, Daniel S, Lonze, Bonnie E, Knabel, Matthew K, Melville Williams, George M, Locke, Jayme E, Montgomery, Robert A, Cameron, Andrew M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD34 - immunology Carbon Tetrachloride Female Flow Cytometry Granulocyte Colony-Stimulating Factor - therapeutic use Hematopoietic Stem Cell Mobilization - methods Heterocyclic Compounds - therapeutic use Immunohistochemistry Liver - immunology Liver - pathology Liver Failure, Acute - chemically induced Liver Failure, Acute - drug therapy Liver Failure, Acute - pathology Mice Rats Rats, Inbred Lew Transaminases - blood
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