Designing helical peptide inhibitors of protein–protein interactions

•Protein interactions mediated by helices can be inhibited with designed peptides.•Peptides must bind tightly and selectively, resist proteolysis and enter cells.•Library methods, modeling, and modification chemistry should be integrated in design.•Targets of recent interest include coiled coils, Bc...

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Veröffentlicht in:	Current opinion in structural biology 2016-08, Vol.39, p.27-38
Hauptverfasser:	Rezaei Araghi, Raheleh, Keating, Amy E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Drug Design Humans Peptides - chemistry Peptides - pharmacology Protein Binding - drug effects Protein Conformation, alpha-Helical Proteins - chemistry Proteins - metabolism
Online-Zugang:	Volltext
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