HSP90 inhibition sensitizes head and neck cancer to platin-based chemoradiotherapy by modulation of the DNA damage response resulting in chromosomal fragmentation

Concurrent cisplatin radiotherapy (CCRT) is a current standard-of-care for locally advanced head and neck squamous cell carcinoma (HNSCC). However, CCRT is frequently ineffective in patients with advanced disease. It has previously been shown that HSP90 inhibitors act as radiosensitizers, but these...

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Veröffentlicht in:	BMC cancer 2017-01, Vol.17 (1), p.86, Article 86
Hauptverfasser:	McLaughlin, Martin, Barker, Holly E, Khan, Aadil A, Pedersen, Malin, Dillon, Magnus, Mansfield, David C, Patel, Radhika, Kyula, Joan N, Bhide, Shreerang A, Newbold, Kate L, Nutting, Christopher M, Harrington, Kevin J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antigens Automation BRCA1 Protein - genetics Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - radiotherapy Care and treatment Cell cycle Cell Line, Tumor Chemoradiotherapy - methods Chromosomes - drug effects Chromosomes - genetics Cisplatin DNA damage DNA Damage - drug effects DNA Damage - genetics DNA Damage - radiation effects DNA Fragmentation - drug effects DNA repair DNA Repair - drug effects DNA Repair - genetics DNA Repair - radiation effects Dosage and administration Female Head and neck cancer Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - genetics Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - radiotherapy Homologous Recombination - drug effects HSP90 Heat-Shock Proteins - antagonists & inhibitors Human papillomavirus Humans Isoxazoles - pharmacology Medical prognosis Mice, Inbred BALB C Mice, Nude Organoplatinum Compounds - pharmacology Plasmids Protein Kinase Inhibitors - pharmacology Proteins Radiation therapy Radiotherapy Resorcinols - pharmacology Squamous Cell Carcinoma of Head and Neck Tumor Suppressor Protein p53 - genetics
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