Lysosomal dysfunction and autophagy blockade contribute to IMB-6G-induced apoptosis in pancreatic cancer cells

Targeting the autophagic pathway is currently regarded as an attractive strategy for cancer drug discovery. Our previous work showed that IMB-6G is a novel N -substituted sophoridinic acid derivative with potent cytotoxicity against tumor cells, yet the effect of IMB-6G on autophagy and pancreatic c...

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Veröffentlicht in:	Scientific reports 2017-01, Vol.7 (1), p.41862-41862, Article 41862
Hauptverfasser:	Liu, Lu, Zhang, Na, Dou, Yueying, Mao, Genxiang, Bi, Chongwen, Pang, Weiqiang, Liu, Xiaojia, Song, Danqing, Deng, Hongbin
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/2 13/31 13/89 13/95 14/19 631/67/1059/99 631/80/39/2346 631/80/82/23 82/29 96/106 96/34 Antineoplastic Agents - pharmacology Apoptosis Autophagy Autophagy-Related Protein 5 - genetics Autophagy-Related Protein 5 - metabolism Caspase Cathepsin B Cathepsin D Cathepsins - metabolism Cell death Cell Line, Tumor Cytoplasm Cytotoxicity Drug discovery Humanities and Social Sciences Humans Lysosomes Lysosomes - drug effects Lysosomes - metabolism multidisciplinary Nitrogen Mustard Compounds - pharmacology Pancreatic cancer Pancreatic Neoplasms - metabolism Phagocytosis Science Science (multidisciplinary) siRNA Tumor cells Vacuoles
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