Basal Forebrain Cholinergic System and Orexin Neurons: Effects on Attention
The basal forebrain (BF) cholinergic system has an important role in attentive functions. The cholinergic system can be activated by different inputs, and in particular, by orexin neurons, whose cell bodies are located within the postero-lateral hypothalamus. Recently the orexin-producing neurons ha...
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| Veröffentlicht in: | Frontiers in behavioral neuroscience 2017-01, Vol.11, p.10-10 |
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| creator | Villano, Ines Messina, Antonietta Valenzano, Anna Moscatelli, Fiorenzo Esposito, Teresa Monda, Vincenzo Esposito, Maria Precenzano, Francesco Carotenuto, Marco Viggiano, Andrea Chieffi, Sergio Cibelli, Giuseppe Monda, Marcellino Messina, Giovanni |
| description | The basal forebrain (BF) cholinergic system has an important role in attentive functions. The cholinergic system can be activated by different inputs, and in particular, by orexin neurons, whose cell bodies are located within the postero-lateral hypothalamus. Recently the orexin-producing neurons have been proved to promote arousal and attention through their projections to the BF. The aim of this review article is to summarize the evidence showing that the orexin system contributes to attentional processing by an increase in cortical acetylcholine release and in cortical neurons activity. |
| doi_str_mv | 10.3389/fnbeh.2017.00010 |
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The cholinergic system can be activated by different inputs, and in particular, by orexin neurons, whose cell bodies are located within the postero-lateral hypothalamus. Recently the orexin-producing neurons have been proved to promote arousal and attention through their projections to the BF. The aim of this review article is to summarize the evidence showing that the orexin system contributes to attentional processing by an increase in cortical acetylcholine release and in cortical neurons activity.</description><identifier>ISSN: 1662-5153</identifier><identifier>EISSN: 1662-5153</identifier><identifier>DOI: 10.3389/fnbeh.2017.00010</identifier><identifier>PMID: 28197081</identifier><language>eng</language><publisher>Switzerland: Frontiers Research Foundation</publisher><subject>Acetylcholine ; Arousal ; Attention ; Basal forebrain ; Cerebrum ; Cholinergic transmission ; Dopamine ; Forebrain ; Hypothalamus (lateral) ; Neurons ; Neuroscience ; Neurosciences ; Orexins ; Physiology ; Prefrontal cortex ; Preventive medicine ; Sleep</subject><ispartof>Frontiers in behavioral neuroscience, 2017-01, Vol.11, p.10-10</ispartof><rights>2017. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2017 Villano, Messina, Valenzano, Moscatelli, Esposito, Monda, Esposito, Precenzano, Carotenuto, Viggiano, Chieffi, Cibelli, Monda and Messina. 2017 Villano, Messina, Valenzano, Moscatelli, Esposito, Monda, Esposito, Precenzano, Carotenuto, Viggiano, Chieffi, Cibelli, Monda and Messina</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-a9502158437358b7ba8a33332e448aaf9b8d0f765fb303519c79cb0fef54d9433</citedby><cites>FETCH-LOGICAL-c490t-a9502158437358b7ba8a33332e448aaf9b8d0f765fb303519c79cb0fef54d9433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5281635/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5281635/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28197081$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Villano, Ines</creatorcontrib><creatorcontrib>Messina, Antonietta</creatorcontrib><creatorcontrib>Valenzano, Anna</creatorcontrib><creatorcontrib>Moscatelli, Fiorenzo</creatorcontrib><creatorcontrib>Esposito, Teresa</creatorcontrib><creatorcontrib>Monda, Vincenzo</creatorcontrib><creatorcontrib>Esposito, Maria</creatorcontrib><creatorcontrib>Precenzano, Francesco</creatorcontrib><creatorcontrib>Carotenuto, Marco</creatorcontrib><creatorcontrib>Viggiano, Andrea</creatorcontrib><creatorcontrib>Chieffi, Sergio</creatorcontrib><creatorcontrib>Cibelli, Giuseppe</creatorcontrib><creatorcontrib>Monda, Marcellino</creatorcontrib><creatorcontrib>Messina, Giovanni</creatorcontrib><title>Basal Forebrain Cholinergic System and Orexin Neurons: Effects on Attention</title><title>Frontiers in behavioral neuroscience</title><addtitle>Front Behav Neurosci</addtitle><description>The basal forebrain (BF) cholinergic system has an important role in attentive functions. The cholinergic system can be activated by different inputs, and in particular, by orexin neurons, whose cell bodies are located within the postero-lateral hypothalamus. Recently the orexin-producing neurons have been proved to promote arousal and attention through their projections to the BF. The aim of this review article is to summarize the evidence showing that the orexin system contributes to attentional processing by an increase in cortical acetylcholine release and in cortical neurons activity.</description><subject>Acetylcholine</subject><subject>Arousal</subject><subject>Attention</subject><subject>Basal forebrain</subject><subject>Cerebrum</subject><subject>Cholinergic transmission</subject><subject>Dopamine</subject><subject>Forebrain</subject><subject>Hypothalamus (lateral)</subject><subject>Neurons</subject><subject>Neuroscience</subject><subject>Neurosciences</subject><subject>Orexins</subject><subject>Physiology</subject><subject>Prefrontal cortex</subject><subject>Preventive medicine</subject><subject>Sleep</subject><issn>1662-5153</issn><issn>1662-5153</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkTFPwzAQhS0EglLYmVAkFpaUc2wnNgNSqSggKjoAs-WkNg1KbbATBP8e00JVuMUn3bvne_oQOsIwIISLM2NLPR9kgIsBAGDYQj2c51nKMCPbG_0e2g_hBSDPclrsor2MY1EAxz10d6mCapKx87r0qrbJaO6a2mr_XFfJw2do9SJRdpZMvf6I03vdeWfDeXJljK7akDibDNtW27Z29gDtGNUEffjz9tHT-OpxdJNOpte3o-EkraiANlWCQYYZp6QgjJdFqbgisTJNKVfKiJLPwBQ5MyUBwrCoClGVYLRhdCYoIX10sfJ97cqFnlXxd68a-errhfKf0qla_p3Yei6f3btkMXdOWDQ4_THw7q3ToZWLOlS6aZTVrgsS85znQgDDUXryT_riOm9jPJllQtCCsnhSH8FKVXkXgtdmfQwG-U1KLknJb1JySSquHG-GWC_8oiFf67iPYQ</recordid><startdate>20170131</startdate><enddate>20170131</enddate><creator>Villano, Ines</creator><creator>Messina, Antonietta</creator><creator>Valenzano, Anna</creator><creator>Moscatelli, Fiorenzo</creator><creator>Esposito, Teresa</creator><creator>Monda, Vincenzo</creator><creator>Esposito, Maria</creator><creator>Precenzano, Francesco</creator><creator>Carotenuto, Marco</creator><creator>Viggiano, Andrea</creator><creator>Chieffi, Sergio</creator><creator>Cibelli, Giuseppe</creator><creator>Monda, Marcellino</creator><creator>Messina, Giovanni</creator><general>Frontiers Research Foundation</general><general>Frontiers Media S.A</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7XB</scope><scope>88I</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170131</creationdate><title>Basal Forebrain Cholinergic System and Orexin Neurons: Effects on Attention</title><author>Villano, Ines ; Messina, Antonietta ; Valenzano, Anna ; Moscatelli, Fiorenzo ; Esposito, Teresa ; Monda, Vincenzo ; Esposito, Maria ; Precenzano, Francesco ; Carotenuto, Marco ; Viggiano, Andrea ; Chieffi, Sergio ; Cibelli, Giuseppe ; Monda, Marcellino ; Messina, Giovanni</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-a9502158437358b7ba8a33332e448aaf9b8d0f765fb303519c79cb0fef54d9433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acetylcholine</topic><topic>Arousal</topic><topic>Attention</topic><topic>Basal forebrain</topic><topic>Cerebrum</topic><topic>Cholinergic transmission</topic><topic>Dopamine</topic><topic>Forebrain</topic><topic>Hypothalamus (lateral)</topic><topic>Neurons</topic><topic>Neuroscience</topic><topic>Neurosciences</topic><topic>Orexins</topic><topic>Physiology</topic><topic>Prefrontal cortex</topic><topic>Preventive medicine</topic><topic>Sleep</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Villano, Ines</creatorcontrib><creatorcontrib>Messina, Antonietta</creatorcontrib><creatorcontrib>Valenzano, Anna</creatorcontrib><creatorcontrib>Moscatelli, Fiorenzo</creatorcontrib><creatorcontrib>Esposito, Teresa</creatorcontrib><creatorcontrib>Monda, Vincenzo</creatorcontrib><creatorcontrib>Esposito, Maria</creatorcontrib><creatorcontrib>Precenzano, Francesco</creatorcontrib><creatorcontrib>Carotenuto, Marco</creatorcontrib><creatorcontrib>Viggiano, Andrea</creatorcontrib><creatorcontrib>Chieffi, Sergio</creatorcontrib><creatorcontrib>Cibelli, Giuseppe</creatorcontrib><creatorcontrib>Monda, Marcellino</creatorcontrib><creatorcontrib>Messina, Giovanni</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Science Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Frontiers in behavioral neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Villano, Ines</au><au>Messina, Antonietta</au><au>Valenzano, Anna</au><au>Moscatelli, Fiorenzo</au><au>Esposito, Teresa</au><au>Monda, Vincenzo</au><au>Esposito, Maria</au><au>Precenzano, Francesco</au><au>Carotenuto, Marco</au><au>Viggiano, Andrea</au><au>Chieffi, Sergio</au><au>Cibelli, Giuseppe</au><au>Monda, Marcellino</au><au>Messina, Giovanni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Basal Forebrain Cholinergic System and Orexin Neurons: Effects on Attention</atitle><jtitle>Frontiers in behavioral neuroscience</jtitle><addtitle>Front Behav Neurosci</addtitle><date>2017-01-31</date><risdate>2017</risdate><volume>11</volume><spage>10</spage><epage>10</epage><pages>10-10</pages><issn>1662-5153</issn><eissn>1662-5153</eissn><abstract>The basal forebrain (BF) cholinergic system has an important role in attentive functions. The cholinergic system can be activated by different inputs, and in particular, by orexin neurons, whose cell bodies are located within the postero-lateral hypothalamus. Recently the orexin-producing neurons have been proved to promote arousal and attention through their projections to the BF. The aim of this review article is to summarize the evidence showing that the orexin system contributes to attentional processing by an increase in cortical acetylcholine release and in cortical neurons activity.</abstract><cop>Switzerland</cop><pub>Frontiers Research Foundation</pub><pmid>28197081</pmid><doi>10.3389/fnbeh.2017.00010</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acetylcholine Arousal Attention Basal forebrain Cerebrum Cholinergic transmission Dopamine Forebrain Hypothalamus (lateral) Neurons Neuroscience Neurosciences Orexins Physiology Prefrontal cortex Preventive medicine Sleep |
| title | Basal Forebrain Cholinergic System and Orexin Neurons: Effects on Attention |
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