Plasma marker of tissue oxidative damage and edaravone as a scavenger drug against peroxyl radicals and peroxynitrite
The percentage of the plasma oxidized form of coenzyme Q10 in the total amount of coenzyme Q10 (%CoQ10) is a useful marker of oxidative stress in the circulation. Plasma free fatty acids and their composition can be used as markers of tissue oxidative damage, as demonstrated in patients suffering fr...
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| Veröffentlicht in: | Journal of Clinical Biochemistry and Nutrition 2017, Vol.60(1), pp.49-54 |
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| container_title | Journal of Clinical Biochemistry and Nutrition |
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| creator | Yamamoto, Yorihiro |
| description | The percentage of the plasma oxidized form of coenzyme Q10 in the total amount of coenzyme Q10 (%CoQ10) is a useful marker of oxidative stress in the circulation. Plasma free fatty acids and their composition can be used as markers of tissue oxidative damage, as demonstrated in patients suffering from a wide variety of diseases and in humans and rats under oxidative stress. Edaravone was approved for the treatment of stroke in Japan in 2001 and its mechanism of action is based on scavenging lipid peroxyl radicals. In 2015, edaravone was also approved for the treatment of ALS patients. Edaravone functions therapeutically as a scavenger of peroxynitrite, as demonstrated by the finding that its administration raises plasma uric acid levels and decreases 3-nitrotyrosine in cerebrospinal fluid. |
| doi_str_mv | 10.3164/jcbn.16-63 |
| format | Article |
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Plasma free fatty acids and their composition can be used as markers of tissue oxidative damage, as demonstrated in patients suffering from a wide variety of diseases and in humans and rats under oxidative stress. Edaravone was approved for the treatment of stroke in Japan in 2001 and its mechanism of action is based on scavenging lipid peroxyl radicals. In 2015, edaravone was also approved for the treatment of ALS patients. 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Clin. Biochem. Nutr.</addtitle><description>The percentage of the plasma oxidized form of coenzyme Q10 in the total amount of coenzyme Q10 (%CoQ10) is a useful marker of oxidative stress in the circulation. Plasma free fatty acids and their composition can be used as markers of tissue oxidative damage, as demonstrated in patients suffering from a wide variety of diseases and in humans and rats under oxidative stress. Edaravone was approved for the treatment of stroke in Japan in 2001 and its mechanism of action is based on scavenging lipid peroxyl radicals. In 2015, edaravone was also approved for the treatment of ALS patients. Edaravone functions therapeutically as a scavenger of peroxynitrite, as demonstrated by the finding that its administration raises plasma uric acid levels and decreases 3-nitrotyrosine in cerebrospinal fluid.</description><subject>ALS</subject><subject>Cerebrospinal fluid</subject><subject>Coenzyme Q10</subject><subject>coenzyme Q10 redox balance</subject><subject>Damage</subject><subject>edaravone</subject><subject>Fatty acids</subject><subject>Lipids</subject><subject>Markers</subject><subject>Nitrotyrosine</subject><subject>Oxidation</subject><subject>Oxidative stress</subject><subject>Peroxyl radicals</subject><subject>Peroxynitrite</subject><subject>Plasma</subject><subject>plasma levels of free fatty acids and their composition</subject><subject>Radicals</subject><subject>Review</subject><subject>Scavenging</subject><subject>Uric acid</subject><issn>0912-0009</issn><issn>1880-5086</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNpdkU-PFCEQxYnRuOPoxQ9gSLwYk16h_9BwMZqNu5psogc9kxqo7mXsgRHoye63l9leJ-oFAvWrxyseIS85O2-4aN9tzcafc1GJ5hFZcSlZ1TEpHpMVU7yuGGPqjDxLactYKzrRPiVnteSiaWS9IvO3CdIO6A7iT4w0DDS7lGak4dZZyO6A1MIORqTgLUULEQ7Bl1OiQJOBA_qx9Nk4jxRGcD5luscYbu8mGsE6A1O6b10uvcvRZXxOngylgC8e9jX5cfnp-8Xn6vrr1ZeLj9eVEZzlChR0TfEqBet729ZGiIErhTi0vZRD3XPBUfRKqK5p7YaBBYacd3IwnPXYN2vyftHdz5sdWoM-R5j0Proy750O4PS_Fe9u9BgOuiuvdg0rAm8eBGL4NWPKeueSwWkCj2FOuljruprzXhX09X_oNszRl_F0Xf5aKdkyWai3C2ViSCnicDLDmT6mqY9pai50CWhNXv1t_4T-ia8AHxZgm3LJ6ARAzM5MuGgJpvn9ctQ8lcwNRI2--Q05b7Qq</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Yamamoto, Yorihiro</creator><general>SOCIETY FOR FREE RADICAL RESEARCH JAPAN</general><general>Japan Science and Technology Agency</general><general>the Society for Free Radical Research Japan</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170101</creationdate><title>Plasma marker of tissue oxidative damage and edaravone as a scavenger drug against peroxyl radicals and peroxynitrite</title><author>Yamamoto, Yorihiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c610t-a9a5328186077d42c66f199eef4788f27161e67969534db0ada0e1158fc107e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>ALS</topic><topic>Cerebrospinal fluid</topic><topic>Coenzyme Q10</topic><topic>coenzyme Q10 redox balance</topic><topic>Damage</topic><topic>edaravone</topic><topic>Fatty acids</topic><topic>Lipids</topic><topic>Markers</topic><topic>Nitrotyrosine</topic><topic>Oxidation</topic><topic>Oxidative stress</topic><topic>Peroxyl radicals</topic><topic>Peroxynitrite</topic><topic>Plasma</topic><topic>plasma levels of free fatty acids and their composition</topic><topic>Radicals</topic><topic>Review</topic><topic>Scavenging</topic><topic>Uric acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamamoto, Yorihiro</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Clinical Biochemistry and Nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamamoto, Yorihiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma marker of tissue oxidative damage and edaravone as a scavenger drug against peroxyl radicals and peroxynitrite</atitle><jtitle>Journal of Clinical Biochemistry and Nutrition</jtitle><addtitle>J. Clin. Biochem. Nutr.</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>60</volume><issue>1</issue><spage>49</spage><epage>54</epage><pages>49-54</pages><issn>0912-0009</issn><eissn>1880-5086</eissn><abstract>The percentage of the plasma oxidized form of coenzyme Q10 in the total amount of coenzyme Q10 (%CoQ10) is a useful marker of oxidative stress in the circulation. Plasma free fatty acids and their composition can be used as markers of tissue oxidative damage, as demonstrated in patients suffering from a wide variety of diseases and in humans and rats under oxidative stress. Edaravone was approved for the treatment of stroke in Japan in 2001 and its mechanism of action is based on scavenging lipid peroxyl radicals. In 2015, edaravone was also approved for the treatment of ALS patients. Edaravone functions therapeutically as a scavenger of peroxynitrite, as demonstrated by the finding that its administration raises plasma uric acid levels and decreases 3-nitrotyrosine in cerebrospinal fluid.</abstract><cop>Japan</cop><pub>SOCIETY FOR FREE RADICAL RESEARCH JAPAN</pub><pmid>28163382</pmid><doi>10.3164/jcbn.16-63</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of Clinical Biochemistry and Nutrition, 2017, Vol.60(1), pp.49-54 |
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| language | eng |
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| source | J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | ALS Cerebrospinal fluid Coenzyme Q10 coenzyme Q10 redox balance Damage edaravone Fatty acids Lipids Markers Nitrotyrosine Oxidation Oxidative stress Peroxyl radicals Peroxynitrite Plasma plasma levels of free fatty acids and their composition Radicals Review Scavenging Uric acid |
| title | Plasma marker of tissue oxidative damage and edaravone as a scavenger drug against peroxyl radicals and peroxynitrite |
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