Differential elastic responses to barrier-altering agonists in two types of human lung endothelium

Vascular integrity is primarily determined by endothelial cell (EC) cytoskeletal structure that is differentially regulated by various stimuli. In this study, atomic force microscopy (AFM) was used to characterize structural and mechanical properties in the cytoskeleton of cultured human pulmonary a...

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Veröffentlicht in:	Biochemical and biophysical research communications 2016-09, Vol.478 (2), p.599-605
Hauptverfasser:	Viswanathan, P., Ephstein, Y., Garcia, J.G.N., Cho, M., Dudek, S.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES AFM agonists ATOMIC FORCE MICROSCOPY Barrier regulation Biomechanical Phenomena biomechanics BIOMEDICAL RADIOGRAPHY Cell Line cytoskeleton Cytoskeleton - metabolism DIFFUSION BARRIERS Elastic Modulus ELASTICITY Endothelial cell endothelial cells endothelium Endothelium, Vascular - cytology Endothelium, Vascular - metabolism FTY720 GROWTH FACTORS hepatocyte growth factor Hepatocyte Growth Factor - metabolism Humans image analysis LIVER CELLS Lung - blood supply LUNGS Lysophospholipids - metabolism mechanical properties Microscopy, Atomic Force modulus of elasticity pathophysiology PHOSPHATES PLANT GROWTH pulmonary artery Pulmonary Artery - cytology S1P sphingosine Sphingosine - analogs & derivatives Sphingosine - metabolism thrombin Thrombin - metabolism VENTILATION BARRIERS
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