Inhibition of Bromodomain and Extraterminal Domain Family Proteins Ameliorates Experimental Renal Damage

Renal inflammation has a key role in the onset and progression of immune- and nonimmune-mediated renal diseases. Therefore, the search for novel anti-inflammatory pharmacologic targets is of great interest in renal pathology. JQ1, a small molecule inhibitor of bromodomain and extraterminal (BET) pro...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2017-02, Vol.28 (2), p.504-519
Hauptverfasser:	Suarez-Alvarez, Beatriz, Morgado-Pascual, José Luis, Rayego-Mateos, Sandra, Rodriguez, Ramon M, Rodrigues-Diez, Raul, Cannata-Ortiz, Pablo, Sanz, Ana B, Egido, Jesus, Tharaux, Pierre-Louis, Ortiz, Alberto, Lopez-Larrea, Carlos, Ruiz-Ortega, Marta
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Azepines - pharmacology Azepines - therapeutic use Basic Research Chromosomal Proteins, Non-Histone - antagonists & inhibitors Chromosomal Proteins, Non-Histone - physiology Disease Models, Animal Kidney Diseases - drug therapy Kidney Diseases - etiology Male Mice Mice, Inbred C57BL Nuclear Proteins - antagonists & inhibitors Nuclear Proteins - physiology Transcription Factors - antagonists & inhibitors Transcription Factors - physiology Triazoles - pharmacology Triazoles - therapeutic use
Online-Zugang:	Volltext
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