Pharmacokinetic Evaluation of Darunavir Administered Once or Twice Daily in Combination with Ritonavir or the Three-Direct-Acting Antiviral Regimen of Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir in Adults Coinfected with Hepatitis C and Human Immunodeficiency Viruses

The three-direct-acting antiviral (3D) regimen containing ombitasvir, paritaprevir, ritonavir, and dasabuvir with or without ribavirin (RBV) is approved for treatment of hepatitis C virus (HCV) genotype 1 (GT1)/human immunodeficiency virus type 1 (HIV-1) coinfection. Results of a pharmacokinetic sub...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2017-02, Vol.61 (2)
Hauptverfasser:	King, Jennifer R, Khatri, Amit, Trinh, Roger, Viani, Rolando M, Ding, Bifeng, Zha, Jiuhong, Menon, Rajeev
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Anilides Anilides - administration & dosage Anilides - pharmacokinetics Anilides - therapeutic use Antiviral Agents Antiviral Agents - administration & dosage Antiviral Agents - pharmacokinetics Antiviral Agents - therapeutic use Carbamates Carbamates - administration & dosage Carbamates - pharmacokinetics Carbamates - therapeutic use Coinfection - drug therapy Coinfection - metabolism Darunavir Darunavir - administration & dosage Darunavir - pharmacokinetics Darunavir - therapeutic use Drug Administration Schedule Female Hepatitis C - drug therapy Hepatitis C - metabolism Hepatitis C virus HIV Infections - drug therapy HIV Infections - metabolism Human immunodeficiency virus 1 Humans Lentivirus Macrocyclic Compounds Macrocyclic Compounds - administration & dosage Macrocyclic Compounds - pharmacokinetics Macrocyclic Compounds - therapeutic use Male Middle Aged Pharmacology Retroviridae Ritonavir Ritonavir - administration & dosage Ritonavir - pharmacokinetics Ritonavir - therapeutic use Sulfonamides Sulfonamides - administration & dosage Sulfonamides - pharmacokinetics Sulfonamides - therapeutic use Uracil Uracil - administration & dosage Uracil - analogs & derivatives Uracil - pharmacokinetics Uracil - therapeutic use
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