Acetylation promotes TyrRS nuclear translocation to prevent oxidative damage

Tyrosyl-tRNA synthetase (TyrRS) is well known for its essential aminoacylation function in protein synthesis. Recently, TyrRS has been shown to translocate to the nucleus and protect against DNA damage due to oxidative stress. However, the mechanism of TyrRS nuclear localization has not yet been det...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2017-01, Vol.114 (4), p.687-692
Hauptverfasser:	Cao, Xuanye, Li, Chaoqun, Xiao, Siyu, Tang, Yunlan, Huang, Jing, Zhao, Shuan, Li, Xueyu, Li, Jixi, Zhang, Ruilin, Yu, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences DNA damage DNA repair Oxidative stress Protein synthesis Simulation
Online-Zugang:	Volltext
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