Cocapture of cognate and bystander antigens can activate autoreactive B cells

Autoantibodies against myelin oligodendrocyte glycoprotein (MOG) are associated with autoimmune central nervous system diseases like acute disseminated encephalomyelitis (ADEM). For ADEM, it is speculated that a preceding infection is the trigger of the autoimmune response, but the mechanism connect...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2017-01, Vol.114 (4), p.734-739
Hauptverfasser:	Sanderson, Nicholas S. R., Zimmermann, Maria, Eilinger, Luca, Gubser, Céline, Schaeren-Wiemers, Nicole, Lindberg, Raija L. P., Dougan, Stephanie K., Ploegh, Hidde L., Kappos, Ludwig, Derfuss, Tobias
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Antigens, Viral - immunology Autoantibodies - immunology Autoantigens - immunology Autoimmunity - immunology B-Lymphocytes - immunology Biological Sciences Cell Line Cell Membrane - immunology Cells Flow cytometry HEK293 Cells Hemagglutinin Glycoproteins, Influenza Virus - immunology Humans Influenza Membranes Mice Mice, Inbred C57BL Myelin-Oligodendrocyte Glycoprotein - immunology Receptors, Antigen, B-Cell - immunology T-Lymphocytes - immunology
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