Computational predictors fail to identify amino acid substitution effects at rheostat positions

Many computational approaches exist for predicting the effects of amino acid substitutions. Here, we considered whether the protein sequence position class – rheostat or toggle – affects these predictions. The classes are defined as follows: experimentally evaluated effects of amino acid substitutio...

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Veröffentlicht in:	Scientific reports 2017-01, Vol.7 (1), p.41329-41329, Article 41329
Hauptverfasser:	Miller, M., Bromberg, Y., Swint-Kruse, L.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/114/2410 631/57/2266 Amino acid substitution Amino Acid Substitution - genetics Amino acids Computer applications Computer Simulation Conservation Humanities and Social Sciences Lac Repressors - chemistry LacI protein Models, Molecular multidisciplinary Science
Online-Zugang:	Volltext
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