ROS-Dependent Activation of Autophagy through the PI3K/Akt/mTOR Pathway Is Induced by Hydroxysafflor Yellow A-Sonodynamic Therapy in THP-1 Macrophages

Monocyte-derived macrophages participate in infaust inflammatory responses by secreting various types of proinflammatory factors, resulting in further inflammatory reactions in atherosclerotic plaques. Autophagy plays an important role in inhibiting inflammation; thus, increasing autophagy may be a...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2017-01, Vol.2017 (2017), p.1-16
Hauptverfasser:	Yang, Liming, Tian, Ye, Liu, Zhongni, Zhong, Zhaoyu, Li, Xuesong, Han, Xiaobo, Kou, Jiayuan, Jiang, Yueqing, Zheng, Yinghong
Format:	Artikel
Sprache:	eng
Schlagworte:	Atherosclerosis Autophagy Autophagy - drug effects Blotting, Western Cell Line Cell Survival - drug effects Chalcone - analogs & derivatives Chalcone - pharmacology Cysteine Cystine Enzyme-Linked Immunosorbent Assay Fluorescent Antibody Technique Gene Knockdown Techniques Health aspects Herbal medicine Humans Inflammation Kinases Macrophages Macrophages - drug effects Microscopy, Electron, Transmission Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Proto-Oncogene Proteins c-akt - metabolism Quinones - pharmacology Reactive Oxygen Species - metabolism Science Signal Transduction - drug effects Signal Transduction - physiology Studies TOR Serine-Threonine Kinases - metabolism Tumor necrosis factor-TNF Ultrasonic imaging Ultrasonic Therapy - methods
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