RNA-Binding Protein Dnd1 Promotes Breast Cancer Apoptosis by Stabilizing the Bim mRNA in a miR-221 Binding Site

RNA-binding proteins (RBPs) and miRNAs are capable of controlling processes in normal development and cancer. Both of them could determine RNA transcripts fate from synthesis to decay. One such RBP, Dead end (Dnd1), is essential for regulating germ-cell viability and suppresses the germ-cell tumors...

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Veröffentlicht in:	BioMed research international 2017-01, Vol.2017 (2017), p.1-10
Hauptverfasser:	Zhu, Lei, Lu, Yi-Min, Pan, Ying, Cheng, Feng, Chen, Shuzheng
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Apoptosis Apoptosis - genetics Bcl-2-Like Protein 11 - genetics Bcl-2-Like Protein 11 - metabolism Binding proteins Binding Sites Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Chinese medicine Competition Cyclin-dependent kinases Development and progression Female Gene expression Gene Expression Regulation, Neoplastic Health aspects Hospitals Humans Kinases MCF-7 Cells Messenger RNA Methods MicroRNA MicroRNAs - genetics MicroRNAs - metabolism Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Protein binding Protein Binding - genetics Proteins RNA sequencing RNA Stability - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Roles Studies Surgery Tumors
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