Effects of Tibolone on the Central Nervous System: Clinical and Experimental Approaches
Hormone replacement therapy (HRT) increases the risk of endometrial and breast cancer. A strategy to reduce this incidence is the use of tibolone (TIB). The aim of this paper was to address the effects of TIB on the central nervous system (CNS). For the present review, MEDLINE (via PubMed), LILACS (...
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| description | Hormone replacement therapy (HRT) increases the risk of endometrial and breast cancer. A strategy to reduce this incidence is the use of tibolone (TIB). The aim of this paper was to address the effects of TIB on the central nervous system (CNS). For the present review, MEDLINE (via PubMed), LILACS (via BIREME), Ovid Global Health, SCOPUS, Scielo, and PsycINFO (ProQuest Research Library) electronic databases were searched for the results of controlled clinical trials on peri- and postmenopausal women published from 1990 to September 2016. Also, this paper reviews experimental studies performed to analyze neuroprotective effects, cognitive deficits, neuroplasticity, oxidative stress, and stroke using TIB. Although there are few studies on the effect of this hormone in the CNS, it has been reported that TIB decreases lipid peroxidation levels and improves memory and learning. TIB has important neuroprotective effects that could prevent the risk of neurodegenerative diseases in postmenopausal women as well as the benefits of HRT in counteracting hot flashes, improving mood, and libido. Some reports have found that TIB delays cognitive impairment in various models of neuronal damage. It also modifies brain plasticity since it acts as an endocrine modulator regulating neurotransmitters, Tau phosphorylation, and decreasing neuronal death. Finally, its antioxidant effects have also been reported in different animal models. |
| doi_str_mv | 10.1155/2017/8630764 |
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A strategy to reduce this incidence is the use of tibolone (TIB). The aim of this paper was to address the effects of TIB on the central nervous system (CNS). For the present review, MEDLINE (via PubMed), LILACS (via BIREME), Ovid Global Health, SCOPUS, Scielo, and PsycINFO (ProQuest Research Library) electronic databases were searched for the results of controlled clinical trials on peri- and postmenopausal women published from 1990 to September 2016. Also, this paper reviews experimental studies performed to analyze neuroprotective effects, cognitive deficits, neuroplasticity, oxidative stress, and stroke using TIB. Although there are few studies on the effect of this hormone in the CNS, it has been reported that TIB decreases lipid peroxidation levels and improves memory and learning. TIB has important neuroprotective effects that could prevent the risk of neurodegenerative diseases in postmenopausal women as well as the benefits of HRT in counteracting hot flashes, improving mood, and libido. Some reports have found that TIB delays cognitive impairment in various models of neuronal damage. It also modifies brain plasticity since it acts as an endocrine modulator regulating neurotransmitters, Tau phosphorylation, and decreasing neuronal death. Finally, its antioxidant effects have also been reported in different animal models.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2017/8630764</identifier><identifier>PMID: 28191467</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Alzheimer's disease ; Analysis ; Cancer ; Cancer therapies ; Central Nervous System - drug effects ; Central nervous system diseases ; Climacteric - drug effects ; Cognition Disorders - drug therapy ; Complications and side effects ; Estrogens ; Hormone replacement therapy ; Hormone therapy ; Hospitals ; Humans ; Menopause ; Metabolism ; Metabolites ; Nervous system ; Neurodegeneration ; Neuronal Plasticity - drug effects ; Norpregnenes - chemistry ; Norpregnenes - pharmacology ; Norpregnenes - therapeutic use ; Osteoporosis ; Oxidative Stress - drug effects ; Prevention ; Review ; Risk factors ; Small intestine ; Stroke ; Studies ; Womens health</subject><ispartof>BioMed research international, 2017-01, Vol.2017 (2017), p.1-9</ispartof><rights>Copyright © 2017 Rodolfo Pinto-Almazán et al.</rights><rights>COPYRIGHT 2017 John Wiley & Sons, Inc.</rights><rights>Copyright © 2017 Rodolfo Pinto-Almazán et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2017 Rodolfo Pinto-Almazán et al. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c532t-dcb7871ec4dfd87bbeb215099a9142e92f67d3b4e0e140b3422f8a8ddeff31b13</citedby><cites>FETCH-LOGICAL-c532t-dcb7871ec4dfd87bbeb215099a9142e92f67d3b4e0e140b3422f8a8ddeff31b13</cites><orcidid>0000-0002-7164-4116 ; 0000-0002-0676-5667</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278195/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278195/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28191467$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Aliev, Gjumrakch</contributor><creatorcontrib>Guerra-Araiza, Christian</creatorcontrib><creatorcontrib>Farfán-García, Eunice D.</creatorcontrib><creatorcontrib>Segura-Uribe, Julia J.</creatorcontrib><creatorcontrib>Pinto-Almazán, Rodolfo</creatorcontrib><title>Effects of Tibolone on the Central Nervous System: Clinical and Experimental Approaches</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Hormone replacement therapy (HRT) increases the risk of endometrial and breast cancer. A strategy to reduce this incidence is the use of tibolone (TIB). The aim of this paper was to address the effects of TIB on the central nervous system (CNS). For the present review, MEDLINE (via PubMed), LILACS (via BIREME), Ovid Global Health, SCOPUS, Scielo, and PsycINFO (ProQuest Research Library) electronic databases were searched for the results of controlled clinical trials on peri- and postmenopausal women published from 1990 to September 2016. Also, this paper reviews experimental studies performed to analyze neuroprotective effects, cognitive deficits, neuroplasticity, oxidative stress, and stroke using TIB. Although there are few studies on the effect of this hormone in the CNS, it has been reported that TIB decreases lipid peroxidation levels and improves memory and learning. TIB has important neuroprotective effects that could prevent the risk of neurodegenerative diseases in postmenopausal women as well as the benefits of HRT in counteracting hot flashes, improving mood, and libido. Some reports have found that TIB delays cognitive impairment in various models of neuronal damage. It also modifies brain plasticity since it acts as an endocrine modulator regulating neurotransmitters, Tau phosphorylation, and decreasing neuronal death. Finally, its antioxidant effects have also been reported in different animal models.</description><subject>Alzheimer's disease</subject><subject>Analysis</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Central Nervous System - drug effects</subject><subject>Central nervous system diseases</subject><subject>Climacteric - drug effects</subject><subject>Cognition Disorders - drug therapy</subject><subject>Complications and side effects</subject><subject>Estrogens</subject><subject>Hormone replacement therapy</subject><subject>Hormone therapy</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Menopause</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Nervous system</subject><subject>Neurodegeneration</subject><subject>Neuronal Plasticity - drug effects</subject><subject>Norpregnenes - chemistry</subject><subject>Norpregnenes - pharmacology</subject><subject>Norpregnenes - therapeutic use</subject><subject>Osteoporosis</subject><subject>Oxidative Stress - 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drug effects</topic><topic>Central nervous system diseases</topic><topic>Climacteric - drug effects</topic><topic>Cognition Disorders - drug therapy</topic><topic>Complications and side effects</topic><topic>Estrogens</topic><topic>Hormone replacement therapy</topic><topic>Hormone therapy</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Menopause</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Nervous system</topic><topic>Neurodegeneration</topic><topic>Neuronal Plasticity - drug effects</topic><topic>Norpregnenes - chemistry</topic><topic>Norpregnenes - pharmacology</topic><topic>Norpregnenes - therapeutic use</topic><topic>Osteoporosis</topic><topic>Oxidative Stress - drug effects</topic><topic>Prevention</topic><topic>Review</topic><topic>Risk factors</topic><topic>Small intestine</topic><topic>Stroke</topic><topic>Studies</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guerra-Araiza, Christian</creatorcontrib><creatorcontrib>Farfán-García, Eunice D.</creatorcontrib><creatorcontrib>Segura-Uribe, Julia J.</creatorcontrib><creatorcontrib>Pinto-Almazán, Rodolfo</creatorcontrib><collection>الدوريات العلمية والإحصائية - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guerra-Araiza, Christian</au><au>Farfán-García, Eunice D.</au><au>Segura-Uribe, Julia J.</au><au>Pinto-Almazán, Rodolfo</au><au>Aliev, Gjumrakch</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Tibolone on the Central Nervous System: Clinical and Experimental Approaches</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>2017</volume><issue>2017</issue><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Hormone replacement therapy (HRT) increases the risk of endometrial and breast cancer. A strategy to reduce this incidence is the use of tibolone (TIB). The aim of this paper was to address the effects of TIB on the central nervous system (CNS). For the present review, MEDLINE (via PubMed), LILACS (via BIREME), Ovid Global Health, SCOPUS, Scielo, and PsycINFO (ProQuest Research Library) electronic databases were searched for the results of controlled clinical trials on peri- and postmenopausal women published from 1990 to September 2016. Also, this paper reviews experimental studies performed to analyze neuroprotective effects, cognitive deficits, neuroplasticity, oxidative stress, and stroke using TIB. Although there are few studies on the effect of this hormone in the CNS, it has been reported that TIB decreases lipid peroxidation levels and improves memory and learning. TIB has important neuroprotective effects that could prevent the risk of neurodegenerative diseases in postmenopausal women as well as the benefits of HRT in counteracting hot flashes, improving mood, and libido. Some reports have found that TIB delays cognitive impairment in various models of neuronal damage. It also modifies brain plasticity since it acts as an endocrine modulator regulating neurotransmitters, Tau phosphorylation, and decreasing neuronal death. Finally, its antioxidant effects have also been reported in different animal models.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>28191467</pmid><doi>10.1155/2017/8630764</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-7164-4116</orcidid><orcidid>https://orcid.org/0000-0002-0676-5667</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Alzheimer's disease Analysis Cancer Cancer therapies Central Nervous System - drug effects Central nervous system diseases Climacteric - drug effects Cognition Disorders - drug therapy Complications and side effects Estrogens Hormone replacement therapy Hormone therapy Hospitals Humans Menopause Metabolism Metabolites Nervous system Neurodegeneration Neuronal Plasticity - drug effects Norpregnenes - chemistry Norpregnenes - pharmacology Norpregnenes - therapeutic use Osteoporosis Oxidative Stress - drug effects Prevention Review Risk factors Small intestine Stroke Studies Womens health |
| title | Effects of Tibolone on the Central Nervous System: Clinical and Experimental Approaches |
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