An independent, landmark-dominated head-direction signal in dysgranular retrosplenial cortex
The authors report on a subpopulation of neurons in retrosplenial cortex that is more sensitive to head direction in a local, visually defined reference frame than to global head direction. These neurons may be the means by which visual landmark information can influence the overall sense of directi...
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| Veröffentlicht in: | Nature neuroscience 2017-02, Vol.20 (2), p.173-175 |
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| creator | Jacob, Pierre-Yves Casali, Giulio Spieser, Laure Page, Hector Overington, Dorothy Jeffery, Kate |
| description | The authors report on a subpopulation of neurons in retrosplenial cortex that is more sensitive to head direction in a local, visually defined reference frame than to global head direction. These neurons may be the means by which visual landmark information can influence the overall sense of direction.
We investigated how landmarks influence the brain's computation of head direction and found that in a bidirectionally symmetrical environment, some neurons in dysgranular retrosplenial cortex showed bidirectional firing patterns. This indicates dominance of neural activity by local environmental cues even when these conflicted with the global head direction signal. It suggests a mechanism for associating landmarks to or dissociating them from the head direction signal, according to their directional stability and/or utility. |
| doi_str_mv | 10.1038/nn.4465 |
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We investigated how landmarks influence the brain's computation of head direction and found that in a bidirectionally symmetrical environment, some neurons in dysgranular retrosplenial cortex showed bidirectional firing patterns. This indicates dominance of neural activity by local environmental cues even when these conflicted with the global head direction signal. It suggests a mechanism for associating landmarks to or dissociating them from the head direction signal, according to their directional stability and/or utility.</description><identifier>ISSN: 1097-6256</identifier><identifier>EISSN: 1546-1726</identifier><identifier>DOI: 10.1038/nn.4465</identifier><identifier>PMID: 27991898</identifier><identifier>CODEN: NANEFN</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>631/378/116 ; 631/378/1595 ; 631/378/2649 ; 631/378/3920 ; 64/86 ; Animal Genetics and Genomics ; Animals ; Behavioral Sciences ; Biological Techniques ; Biomedicine ; Brain - physiology ; brief-communication ; Cognitive science ; Cues ; Head - physiology ; Head Movements - physiology ; Instruments (Equipment) ; Male ; Neurobiology ; Neurons ; Neurons - physiology ; Neuroscience ; Neurosciences ; Odors ; Orientation - physiology ; Rats ; Rotation</subject><ispartof>Nature neuroscience, 2017-02, Vol.20 (2), p.173-175</ispartof><rights>Springer Nature America, Inc. 2016</rights><rights>COPYRIGHT 2017 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Feb 2017</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c598t-588578e16a955cd5138a0921683335035b1a99cfbc170039e2c464d1138873973</citedby><cites>FETCH-LOGICAL-c598t-588578e16a955cd5138a0921683335035b1a99cfbc170039e2c464d1138873973</cites><orcidid>0000-0002-4662-1051</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nn.4465$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nn.4465$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,778,782,883,27911,27912,41475,42544,51306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27991898$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01664366$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Jacob, Pierre-Yves</creatorcontrib><creatorcontrib>Casali, Giulio</creatorcontrib><creatorcontrib>Spieser, Laure</creatorcontrib><creatorcontrib>Page, Hector</creatorcontrib><creatorcontrib>Overington, Dorothy</creatorcontrib><creatorcontrib>Jeffery, Kate</creatorcontrib><title>An independent, landmark-dominated head-direction signal in dysgranular retrosplenial cortex</title><title>Nature neuroscience</title><addtitle>Nat Neurosci</addtitle><addtitle>Nat Neurosci</addtitle><description>The authors report on a subpopulation of neurons in retrosplenial cortex that is more sensitive to head direction in a local, visually defined reference frame than to global head direction. These neurons may be the means by which visual landmark information can influence the overall sense of direction.
We investigated how landmarks influence the brain's computation of head direction and found that in a bidirectionally symmetrical environment, some neurons in dysgranular retrosplenial cortex showed bidirectional firing patterns. This indicates dominance of neural activity by local environmental cues even when these conflicted with the global head direction signal. 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Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nature neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jacob, Pierre-Yves</au><au>Casali, Giulio</au><au>Spieser, Laure</au><au>Page, Hector</au><au>Overington, Dorothy</au><au>Jeffery, Kate</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An independent, landmark-dominated head-direction signal in dysgranular retrosplenial cortex</atitle><jtitle>Nature neuroscience</jtitle><stitle>Nat Neurosci</stitle><addtitle>Nat Neurosci</addtitle><date>2017-02-01</date><risdate>2017</risdate><volume>20</volume><issue>2</issue><spage>173</spage><epage>175</epage><pages>173-175</pages><issn>1097-6256</issn><eissn>1546-1726</eissn><coden>NANEFN</coden><abstract>The authors report on a subpopulation of neurons in retrosplenial cortex that is more sensitive to head direction in a local, visually defined reference frame than to global head direction. These neurons may be the means by which visual landmark information can influence the overall sense of direction.
We investigated how landmarks influence the brain's computation of head direction and found that in a bidirectionally symmetrical environment, some neurons in dysgranular retrosplenial cortex showed bidirectional firing patterns. This indicates dominance of neural activity by local environmental cues even when these conflicted with the global head direction signal. It suggests a mechanism for associating landmarks to or dissociating them from the head direction signal, according to their directional stability and/or utility.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>27991898</pmid><doi>10.1038/nn.4465</doi><tpages>3</tpages><orcidid>https://orcid.org/0000-0002-4662-1051</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 631/378/116 631/378/1595 631/378/2649 631/378/3920 64/86 Animal Genetics and Genomics Animals Behavioral Sciences Biological Techniques Biomedicine Brain - physiology brief-communication Cognitive science Cues Head - physiology Head Movements - physiology Instruments (Equipment) Male Neurobiology Neurons Neurons - physiology Neuroscience Neurosciences Odors Orientation - physiology Rats Rotation |
| title | An independent, landmark-dominated head-direction signal in dysgranular retrosplenial cortex |
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