Metformin promotes the survival of transplanted cardiosphere-derived cells thereby enhancing their therapeutic effect against myocardial infarction

Transplantation of cardiosphere-derived cells (CDCs) has been shown to exert a therapeutic effect in patients with myocardial infarction (MI). However, poor survival of transplanted CDCs limits their beneficial effect. Metformin (MET) activates AMP-activated protein kinase (AMPK) which is associated...

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Veröffentlicht in:	Stem cell research & therapy 2017-01, Vol.8 (1), p.17-17, Article 17
Hauptverfasser:	Yue, Rongchuan, Fu, Wenbin, Liao, Xiang, Lan, Cong, Liao, Qiao, Li, Liangpeng, Yang, Dezhong, Xia, Xuewei, Chen, Xiongwen, Zeng, Chunyu, Wang, Wei Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism Animals Care and treatment Cell Proliferation Cell Survival - drug effects Dosage and administration Fibroblasts - cytology Fibroblasts - metabolism Gene Expression Regulation Genes, Reporter Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Heart attack Humans Hypoglycemic Agents - pharmacology Injections, Intralesional Male Metformin Metformin - pharmacology Mice Mice, Inbred C57BL Mice, Transgenic Myocardial Infarction - genetics Myocardial Infarction - metabolism Myocardial Infarction - pathology Myocardial Infarction - therapy Myocardium - metabolism Myocardium - pathology Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Nitric Oxide Synthase Type III - genetics Nitric Oxide Synthase Type III - metabolism Phosphorylation - drug effects Protein kinases Pyrazoles - pharmacology Pyrimidines - pharmacology Spheroids, Cellular - cytology Spheroids, Cellular - metabolism Spheroids, Cellular - transplantation Stem cells
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