Mitochondria in the spotlight of aging and idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a chronic age-related lung disease with high mortality that is characterized by abnormal scarring of the lung parenchyma. There has been a recent attempt to define the age-associated changes predisposing individuals to develop IPF. Age-related perturbations tha...

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Veröffentlicht in:	The Journal of clinical investigation 2017-02, Vol.127 (2), p.405-414
Hauptverfasser:	Mora, Ana L, Bueno, Marta, Rojas, Mauricio
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Age factors in disease Aging Aging - metabolism Aging - pathology Animals Apoptosis Autophagy Biomedical research Biosynthesis Care and treatment Chronic illnesses Chronic obstructive pulmonary disease Development and progression Exercise Fibroblasts - metabolism Fibroblasts - pathology Genetic aspects Health aspects Homeostasis Humans Idiopathic Pulmonary Fibrosis - metabolism Idiopathic Pulmonary Fibrosis - pathology Industrialized nations Lung - metabolism Lung - pathology Lung diseases Lungs Mitochondria Mitochondria - metabolism Mitochondria - pathology Mitochondrial DNA Mortality Older people Population Pulmonary fibrosis Quality of life Repair & maintenance Respiratory Mucosa - metabolism Respiratory Mucosa - pathology Review Rodents Senescence Studies Text editing
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