Hypoxia‐inducible factor 1 promotes chemoresistance of lung cancer by inducing carbonic anhydrase IX expression

Lung cancer treatment is difficult owing to chemoresistance. Hypoxia‐inducible factor 1 (HIF‐1) and HIF‐1‐induced glycolysis are correlated with chemoresistance; however, this is not evident in lung cancer. We investigated the effect of HIF‐1α and carbonic anhydrase IX (CAIX), a transmembrane protei...

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Veröffentlicht in:	Cancer medicine (Malden, MA) MA), 2017-01, Vol.6 (1), p.288-297
Hauptverfasser:	Sowa, Terumasa, Menju, Toshi, Chen‐Yoshikawa, Toyofumi F., Takahashi, Koji, Nishikawa, Shigeto, Nakanishi, Takao, Shikuma, Kei, Motoyama, Hideki, Hijiya, Kyoko, Aoyama, Akihiro, Sato, Toshihiko, Sonobe, Makoto, Harada, Hiroshi, Date, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Acidosis Aged Antigens, Neoplasm - metabolism Cancer Biology Cancer therapies Carbonic anhydrase IX Carbonic Anhydrase IX - metabolism Carbonic anhydrases Cell growth Cell Hypoxia Chemoradiotherapy Chemoresistance Chemotherapy Cytotoxicity Drug Resistance, Neoplasm Experiments Female Glucose transporter Glucose Transporter Type 1 - metabolism Glycolysis Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - metabolism hypoxia‐inducible factor 1 induction chemoradiotherapy Lung cancer Lung Neoplasms - metabolism Lung Neoplasms - therapy Lymphatic system Male Manufacturers Metabolic pathways Metastasis Middle Aged Mutation Original Research Oxidative phosphorylation Patients Phosphorylation Plasmids Prognosis Studies Vinblastine - analogs & derivatives Vinblastine - pharmacology Vinblastine - therapeutic use Vinorelbine
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