Control of bone development by P2X and P2Y receptors expressed in mesenchymal and hematopoietic cells

Bone development and homeostasis require the interplay between several cell types, including mesenchymal osteoblasts and osteocytes, as well as hematopoietic osteoclasts. Recent evidence suggests that cell proliferation, differentiation and apoptosis of both mesenchymal and hematopoietic stem cells,...

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Veröffentlicht in:	Gene 2015-10, Vol.570 (1), p.1-7
Hauptverfasser:	Lenertz, Lisa Y., Baughman, Cory J., Waldschmidt, Noelle V., Thaler, Roman, van Wijnen, Andre J.
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosine triphosphate animal models Animals apoptosis Bone Bone Development bones calcium cell proliferation hematopoietic stem cells Hematopoietic Stem Cells - physiology homeostasis Humans Mesenchymal stem cell Mesenchymal Stromal Cells - physiology mitogen-activated protein kinase Osteoblast osteoblasts Osteoblasts - metabolism osteoclasts Osteoclasts - metabolism Osteogenesis receptors Receptors, Purinergic P2X - physiology Receptors, Purinergic P2Y - physiology shear stress Signal Transduction single nucleotide polymorphism skeletal development surface proteins tissue repair
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