Crumbs2 promotes cell ingression during the epithelial-to-mesenchymal transition at gastrulation

During gastrulation of the mouse embryo, individual cells ingress in an apparently stochastic pattern during the epithelial-to-mesenchymal transition (EMT). Here we define a critical role of the apical protein Crumbs2 (CRB2) in the gastrulation EMT. Static and live imaging show that ingressing cells...

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Veröffentlicht in:	Nature cell biology 2016-12, Vol.18 (12), p.1281-1291
Hauptverfasser:	Ramkumar, Nitya, Omelchenko, Tatiana, Silva-Gagliardi, Nancy F., McGlade, C. Jane, Wijnholds, Jan, Anderson, Kathryn V.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136/2086 631/136/2086/2127 631/136/334/1874/345 Animals Basement Membrane - metabolism Biology Cancer Research Cell Biology Cells Cellular proteins Cytological research Developmental Biology Embryonic development Embryos Epithelial-Mesenchymal Transition Gastrulation Gene expression Genetic aspects Germ Layers - cytology Homeodomain Proteins - metabolism Imaging, Three-Dimensional In Situ Hybridization Insects Life Sciences Mammals - embryology Membrane Proteins - metabolism Mesoderm - cytology Mesoderm - metabolism Mice Morphology Mutation - genetics Nonmuscle Myosin Type IIB - metabolism Primitive Streak - cytology Properties Proteins Stem Cells Transcription factors
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