Endothelial Cell–Specific Deletion of P2Y2 Receptor Promotes Plaque Stability in Atherosclerosis-Susceptible ApoE-Null Mice

OBJECTIVE—Nucleotide P2Y2 receptor (P2Y2R) contributes to vascular inflammation by increasing vascular cell adhesion molecule-1 expression in endothelial cells (EC), and global P2Y2R deficiency prevents fatty streak formation in apolipoprotein E null (ApoE) mice. Because P2Y2R is ubiquitously expres...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2017-01, Vol.37 (1), p.75-83
Hauptverfasser:	Chen, Xingjuan, Qian, Shaomin, Hoggatt, April, Tang, Hongying, Hacker, Timothy A, Obukhov, Alexander G, Herring, Paul B, Seye, Cheikh I
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta, Thoracic - drug effects Aorta, Thoracic - metabolism Aorta, Thoracic - pathology Aorta, Thoracic - physiopathology Aortic Diseases - genetics Aortic Diseases - metabolism Aortic Diseases - pathology Aortic Diseases - prevention & control Apolipoproteins E - deficiency Apolipoproteins E - genetics Atherosclerosis - genetics Atherosclerosis - metabolism Atherosclerosis - pathology Atherosclerosis - prevention & control Cell Movement Cells, Cultured Collagen - metabolism Disease Models, Animal Disease Progression Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelial Cells - pathology Fibrosis Macrophages - metabolism Macrophages - pathology Male Matrix Metalloproteinase 2 - metabolism Mice, Inbred C57BL Mice, Knockout Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology Muscle, Smooth, Vascular - physiopathology Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - pathology Nitric Oxide - metabolism Nitric Oxide Synthase Type III - metabolism Plaque, Atherosclerotic Purinergic P2Y Receptor Agonists - pharmacology Receptors, Purinergic P2Y2 - deficiency Receptors, Purinergic P2Y2 - genetics Rupture, Spontaneous Signal Transduction Vasodilation - drug effects Vasodilator Agents - pharmacology
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