Semipurified Ethyl Acetate Partition of Methanolic Extract of Melastoma malabathricum Leaves Exerts Gastroprotective Activity Partly via Its Antioxidant-Antisecretory-Anti-Inflammatory Action and Synergistic Action of Several Flavonoid-Based Compounds
Recent study has demonstrated the gastroprotective activity of crude methanolic extract of M. malabathricum leaves. The present study evaluated the gastroprotective potential of semipurified extracts (partitions): petroleum ether, ethyl acetate (EAMM), and aqueous obtained from the methanolic extrac...
Gespeichert in:
| Veröffentlicht in: | Oxidative medicine and cellular longevity 2017-01, Vol.2017 (2017), p.1-14 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 14 |
|---|---|
| container_issue | 2017 |
| container_start_page | 1 |
| container_title | Oxidative medicine and cellular longevity |
| container_volume | 2017 |
| creator | Zakaria, Zainul Amiruddin Salleh, M. Z. Cheema, Manraj Singh Tohid, S. F. Md Omar, Maizatul Hasyima Mohtarrudin, N. Noor Azmi, Ahmad Khusairi Ismail Suhaimy, Noor Wahida Teh, L. K. |
| description | Recent study has demonstrated the gastroprotective activity of crude methanolic extract of M. malabathricum leaves. The present study evaluated the gastroprotective potential of semipurified extracts (partitions): petroleum ether, ethyl acetate (EAMM), and aqueous obtained from the methanolic extract followed by the elucidation of the gastroprotective mechanisms of the most effective partition. Using the ethanol-induced gastric ulcer assay, all partitions exerted significant gastroprotection, with EAMM being the most effective partition. EAMM significantly (i) reduced the volume and acidity (free and total) while increasing the pH of gastric juice and enhanced the gastric wall mucus secretion when assessed using the pylorus ligation assay, (ii) increased the enzymatic and nonenzymatic antioxidant activity of the stomach tissue, (iii) lost its gastroprotective activity following pretreatment with N-omega-nitro-L-arginine methyl ester (L-NAME; NO blocker) or carbenoxolone (CBXN; NP-SH blocker), (iv) exerted antioxidant activity against various in vitro oxidation assays, and (v) showed moderate in vitro anti-inflammatory activity via the LOX-modulated pathway. In conclusion, EAMM exerts a remarkable NO/NP-SH-dependent gastroprotective effect that is attributed to its antisecretory and antioxidant activities, ability to stimulate the gastric mucus production and endogenous antioxidant system, and synergistic action of several gastroprotective-induced flavonoids. |
| doi_str_mv | 10.1155/2017/6542631 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5267083</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A555850696</galeid><sourcerecordid>A555850696</sourcerecordid><originalsourceid>FETCH-LOGICAL-c499t-48d2e012cbd1462a8b6467e25dd6950a00a6ad665f00649ccca647302f286b9c3</originalsourceid><addsrcrecordid>eNqNks2P0zAQxSMEYpeFG2dkiQsShLWdxE0uSKXqLpWKQCqco6kzab1y7GI7ZfO3c8FpS_k4cbIz_unNm8lLkueMvmWsKK45ZZNrUeRcZOxBcsmqnKe0qvKH5zulF8kT7-8oFRnP2ePkgpdMlJSxy-THCju1651qFTZkHraDJlOJAQKSz-CCCsoaYlvyEcMWjNVKkvl9cCDDsarBB9sB6UDDGsLWKdl3ZImwRx9JdMGT28g4u3M2oAxqj7FDPFQYDi30QPYKyCKCUxPb3asGTEjHu0fpMFg3HL7ShWk1dB2MlYNGtAamIavBoNsoH6K5Uzl6W-EeHWhyo2FvjVVN-h58HHJmu53tTeOfJo9a0B6fnc6r5OvN_MvsQ7r8dLuYTZepzKsqpHnZcKSMy3XDcsGhXItcTJAXTSOqggKlIKARomjjgvNKSgkin2SUt7wU60pmV8m7o-6uX3fYSDRxf7reOdWBG2oLqv77xahtvbH7uuBiQsssCrw6CTj7rUcf6k55iVqDQdv7mpWiKHlRFpOIvvwHvbO9M3G8kYr-8jIG5UxtQGOtTGvHPzqK1tOiiEJUVCP15khJZ7132J4tM1qP2avH7NWn7EX8xZ9jnuFfYYvA6yOwVaaB7-o_5TAy2MJvmlVxMSz7CY1C8Yk</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1860644826</pqid></control><display><type>article</type><title>Semipurified Ethyl Acetate Partition of Methanolic Extract of Melastoma malabathricum Leaves Exerts Gastroprotective Activity Partly via Its Antioxidant-Antisecretory-Anti-Inflammatory Action and Synergistic Action of Several Flavonoid-Based Compounds</title><source>MEDLINE</source><source>PubMed Central Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Wiley Online Library (Open Access Collection)</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Zakaria, Zainul Amiruddin ; Salleh, M. Z. ; Cheema, Manraj Singh ; Tohid, S. F. Md ; Omar, Maizatul Hasyima ; Mohtarrudin, N. ; Noor Azmi, Ahmad Khusairi ; Ismail Suhaimy, Noor Wahida ; Teh, L. K.</creator><contributor>Romero, Francisco J.</contributor><creatorcontrib>Zakaria, Zainul Amiruddin ; Salleh, M. Z. ; Cheema, Manraj Singh ; Tohid, S. F. Md ; Omar, Maizatul Hasyima ; Mohtarrudin, N. ; Noor Azmi, Ahmad Khusairi ; Ismail Suhaimy, Noor Wahida ; Teh, L. K. ; Romero, Francisco J.</creatorcontrib><description>Recent study has demonstrated the gastroprotective activity of crude methanolic extract of M. malabathricum leaves. The present study evaluated the gastroprotective potential of semipurified extracts (partitions): petroleum ether, ethyl acetate (EAMM), and aqueous obtained from the methanolic extract followed by the elucidation of the gastroprotective mechanisms of the most effective partition. Using the ethanol-induced gastric ulcer assay, all partitions exerted significant gastroprotection, with EAMM being the most effective partition. EAMM significantly (i) reduced the volume and acidity (free and total) while increasing the pH of gastric juice and enhanced the gastric wall mucus secretion when assessed using the pylorus ligation assay, (ii) increased the enzymatic and nonenzymatic antioxidant activity of the stomach tissue, (iii) lost its gastroprotective activity following pretreatment with N-omega-nitro-L-arginine methyl ester (L-NAME; NO blocker) or carbenoxolone (CBXN; NP-SH blocker), (iv) exerted antioxidant activity against various in vitro oxidation assays, and (v) showed moderate in vitro anti-inflammatory activity via the LOX-modulated pathway. In conclusion, EAMM exerts a remarkable NO/NP-SH-dependent gastroprotective effect that is attributed to its antisecretory and antioxidant activities, ability to stimulate the gastric mucus production and endogenous antioxidant system, and synergistic action of several gastroprotective-induced flavonoids.</description><identifier>ISSN: 1942-0900</identifier><identifier>EISSN: 1942-0994</identifier><identifier>DOI: 10.1155/2017/6542631</identifier><identifier>PMID: 28168011</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Acetates ; Acids ; Animals ; Antioxidants ; Care and treatment ; Flavonoids ; Flavonoids - pharmacology ; Health aspects ; Materia medica, Vegetable ; Medicine ; Melastomataceae - chemistry ; Natural products ; Plant extracts ; Plant Extracts - chemistry ; Plant Leaves - chemistry ; Rosidae ; Stomach ulcer ; Stomach Ulcer - drug therapy ; Stomach Ulcer - pathology ; Ulcers</subject><ispartof>Oxidative medicine and cellular longevity, 2017-01, Vol.2017 (2017), p.1-14</ispartof><rights>Copyright © 2017 Noor Wahida Ismail Suhaimy et al.</rights><rights>COPYRIGHT 2017 John Wiley & Sons, Inc.</rights><rights>Copyright © 2017 Noor Wahida Ismail Suhaimy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2017 Noor Wahida Ismail Suhaimy et al. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-48d2e012cbd1462a8b6467e25dd6950a00a6ad665f00649ccca647302f286b9c3</citedby><cites>FETCH-LOGICAL-c499t-48d2e012cbd1462a8b6467e25dd6950a00a6ad665f00649ccca647302f286b9c3</cites><orcidid>0000-0002-4772-1062 ; 0000-0002-9117-9880 ; 0000-0001-9882-0661 ; 0000-0002-4386-412X ; 0000-0001-5525-7821</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267083/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267083/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28168011$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Romero, Francisco J.</contributor><creatorcontrib>Zakaria, Zainul Amiruddin</creatorcontrib><creatorcontrib>Salleh, M. Z.</creatorcontrib><creatorcontrib>Cheema, Manraj Singh</creatorcontrib><creatorcontrib>Tohid, S. F. Md</creatorcontrib><creatorcontrib>Omar, Maizatul Hasyima</creatorcontrib><creatorcontrib>Mohtarrudin, N.</creatorcontrib><creatorcontrib>Noor Azmi, Ahmad Khusairi</creatorcontrib><creatorcontrib>Ismail Suhaimy, Noor Wahida</creatorcontrib><creatorcontrib>Teh, L. K.</creatorcontrib><title>Semipurified Ethyl Acetate Partition of Methanolic Extract of Melastoma malabathricum Leaves Exerts Gastroprotective Activity Partly via Its Antioxidant-Antisecretory-Anti-Inflammatory Action and Synergistic Action of Several Flavonoid-Based Compounds</title><title>Oxidative medicine and cellular longevity</title><addtitle>Oxid Med Cell Longev</addtitle><description>Recent study has demonstrated the gastroprotective activity of crude methanolic extract of M. malabathricum leaves. The present study evaluated the gastroprotective potential of semipurified extracts (partitions): petroleum ether, ethyl acetate (EAMM), and aqueous obtained from the methanolic extract followed by the elucidation of the gastroprotective mechanisms of the most effective partition. Using the ethanol-induced gastric ulcer assay, all partitions exerted significant gastroprotection, with EAMM being the most effective partition. EAMM significantly (i) reduced the volume and acidity (free and total) while increasing the pH of gastric juice and enhanced the gastric wall mucus secretion when assessed using the pylorus ligation assay, (ii) increased the enzymatic and nonenzymatic antioxidant activity of the stomach tissue, (iii) lost its gastroprotective activity following pretreatment with N-omega-nitro-L-arginine methyl ester (L-NAME; NO blocker) or carbenoxolone (CBXN; NP-SH blocker), (iv) exerted antioxidant activity against various in vitro oxidation assays, and (v) showed moderate in vitro anti-inflammatory activity via the LOX-modulated pathway. In conclusion, EAMM exerts a remarkable NO/NP-SH-dependent gastroprotective effect that is attributed to its antisecretory and antioxidant activities, ability to stimulate the gastric mucus production and endogenous antioxidant system, and synergistic action of several gastroprotective-induced flavonoids.</description><subject>Acetates</subject><subject>Acids</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Care and treatment</subject><subject>Flavonoids</subject><subject>Flavonoids - pharmacology</subject><subject>Health aspects</subject><subject>Materia medica, Vegetable</subject><subject>Medicine</subject><subject>Melastomataceae - chemistry</subject><subject>Natural products</subject><subject>Plant extracts</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Leaves - chemistry</subject><subject>Rosidae</subject><subject>Stomach ulcer</subject><subject>Stomach Ulcer - drug therapy</subject><subject>Stomach Ulcer - pathology</subject><subject>Ulcers</subject><issn>1942-0900</issn><issn>1942-0994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNks2P0zAQxSMEYpeFG2dkiQsShLWdxE0uSKXqLpWKQCqco6kzab1y7GI7ZfO3c8FpS_k4cbIz_unNm8lLkueMvmWsKK45ZZNrUeRcZOxBcsmqnKe0qvKH5zulF8kT7-8oFRnP2ePkgpdMlJSxy-THCju1651qFTZkHraDJlOJAQKSz-CCCsoaYlvyEcMWjNVKkvl9cCDDsarBB9sB6UDDGsLWKdl3ZImwRx9JdMGT28g4u3M2oAxqj7FDPFQYDi30QPYKyCKCUxPb3asGTEjHu0fpMFg3HL7ShWk1dB2MlYNGtAamIavBoNsoH6K5Uzl6W-EeHWhyo2FvjVVN-h58HHJmu53tTeOfJo9a0B6fnc6r5OvN_MvsQ7r8dLuYTZepzKsqpHnZcKSMy3XDcsGhXItcTJAXTSOqggKlIKARomjjgvNKSgkin2SUt7wU60pmV8m7o-6uX3fYSDRxf7reOdWBG2oLqv77xahtvbH7uuBiQsssCrw6CTj7rUcf6k55iVqDQdv7mpWiKHlRFpOIvvwHvbO9M3G8kYr-8jIG5UxtQGOtTGvHPzqK1tOiiEJUVCP15khJZ7132J4tM1qP2avH7NWn7EX8xZ9jnuFfYYvA6yOwVaaB7-o_5TAy2MJvmlVxMSz7CY1C8Yk</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Zakaria, Zainul Amiruddin</creator><creator>Salleh, M. Z.</creator><creator>Cheema, Manraj Singh</creator><creator>Tohid, S. F. Md</creator><creator>Omar, Maizatul Hasyima</creator><creator>Mohtarrudin, N.</creator><creator>Noor Azmi, Ahmad Khusairi</creator><creator>Ismail Suhaimy, Noor Wahida</creator><creator>Teh, L. K.</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4772-1062</orcidid><orcidid>https://orcid.org/0000-0002-9117-9880</orcidid><orcidid>https://orcid.org/0000-0001-9882-0661</orcidid><orcidid>https://orcid.org/0000-0002-4386-412X</orcidid><orcidid>https://orcid.org/0000-0001-5525-7821</orcidid></search><sort><creationdate>20170101</creationdate><title>Semipurified Ethyl Acetate Partition of Methanolic Extract of Melastoma malabathricum Leaves Exerts Gastroprotective Activity Partly via Its Antioxidant-Antisecretory-Anti-Inflammatory Action and Synergistic Action of Several Flavonoid-Based Compounds</title><author>Zakaria, Zainul Amiruddin ; Salleh, M. Z. ; Cheema, Manraj Singh ; Tohid, S. F. Md ; Omar, Maizatul Hasyima ; Mohtarrudin, N. ; Noor Azmi, Ahmad Khusairi ; Ismail Suhaimy, Noor Wahida ; Teh, L. K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-48d2e012cbd1462a8b6467e25dd6950a00a6ad665f00649ccca647302f286b9c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acetates</topic><topic>Acids</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Care and treatment</topic><topic>Flavonoids</topic><topic>Flavonoids - pharmacology</topic><topic>Health aspects</topic><topic>Materia medica, Vegetable</topic><topic>Medicine</topic><topic>Melastomataceae - chemistry</topic><topic>Natural products</topic><topic>Plant extracts</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Leaves - chemistry</topic><topic>Rosidae</topic><topic>Stomach ulcer</topic><topic>Stomach Ulcer - drug therapy</topic><topic>Stomach Ulcer - pathology</topic><topic>Ulcers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zakaria, Zainul Amiruddin</creatorcontrib><creatorcontrib>Salleh, M. Z.</creatorcontrib><creatorcontrib>Cheema, Manraj Singh</creatorcontrib><creatorcontrib>Tohid, S. F. Md</creatorcontrib><creatorcontrib>Omar, Maizatul Hasyima</creatorcontrib><creatorcontrib>Mohtarrudin, N.</creatorcontrib><creatorcontrib>Noor Azmi, Ahmad Khusairi</creatorcontrib><creatorcontrib>Ismail Suhaimy, Noor Wahida</creatorcontrib><creatorcontrib>Teh, L. K.</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oxidative medicine and cellular longevity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zakaria, Zainul Amiruddin</au><au>Salleh, M. Z.</au><au>Cheema, Manraj Singh</au><au>Tohid, S. F. Md</au><au>Omar, Maizatul Hasyima</au><au>Mohtarrudin, N.</au><au>Noor Azmi, Ahmad Khusairi</au><au>Ismail Suhaimy, Noor Wahida</au><au>Teh, L. K.</au><au>Romero, Francisco J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Semipurified Ethyl Acetate Partition of Methanolic Extract of Melastoma malabathricum Leaves Exerts Gastroprotective Activity Partly via Its Antioxidant-Antisecretory-Anti-Inflammatory Action and Synergistic Action of Several Flavonoid-Based Compounds</atitle><jtitle>Oxidative medicine and cellular longevity</jtitle><addtitle>Oxid Med Cell Longev</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>2017</volume><issue>2017</issue><spage>1</spage><epage>14</epage><pages>1-14</pages><issn>1942-0900</issn><eissn>1942-0994</eissn><abstract>Recent study has demonstrated the gastroprotective activity of crude methanolic extract of M. malabathricum leaves. The present study evaluated the gastroprotective potential of semipurified extracts (partitions): petroleum ether, ethyl acetate (EAMM), and aqueous obtained from the methanolic extract followed by the elucidation of the gastroprotective mechanisms of the most effective partition. Using the ethanol-induced gastric ulcer assay, all partitions exerted significant gastroprotection, with EAMM being the most effective partition. EAMM significantly (i) reduced the volume and acidity (free and total) while increasing the pH of gastric juice and enhanced the gastric wall mucus secretion when assessed using the pylorus ligation assay, (ii) increased the enzymatic and nonenzymatic antioxidant activity of the stomach tissue, (iii) lost its gastroprotective activity following pretreatment with N-omega-nitro-L-arginine methyl ester (L-NAME; NO blocker) or carbenoxolone (CBXN; NP-SH blocker), (iv) exerted antioxidant activity against various in vitro oxidation assays, and (v) showed moderate in vitro anti-inflammatory activity via the LOX-modulated pathway. In conclusion, EAMM exerts a remarkable NO/NP-SH-dependent gastroprotective effect that is attributed to its antisecretory and antioxidant activities, ability to stimulate the gastric mucus production and endogenous antioxidant system, and synergistic action of several gastroprotective-induced flavonoids.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>28168011</pmid><doi>10.1155/2017/6542631</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-4772-1062</orcidid><orcidid>https://orcid.org/0000-0002-9117-9880</orcidid><orcidid>https://orcid.org/0000-0001-9882-0661</orcidid><orcidid>https://orcid.org/0000-0002-4386-412X</orcidid><orcidid>https://orcid.org/0000-0001-5525-7821</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1942-0900 |
| ispartof | Oxidative medicine and cellular longevity, 2017-01, Vol.2017 (2017), p.1-14 |
| issn | 1942-0900 1942-0994 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5267083 |
| source | MEDLINE; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection); PubMed Central; Alma/SFX Local Collection |
| subjects | Acetates Acids Animals Antioxidants Care and treatment Flavonoids Flavonoids - pharmacology Health aspects Materia medica, Vegetable Medicine Melastomataceae - chemistry Natural products Plant extracts Plant Extracts - chemistry Plant Leaves - chemistry Rosidae Stomach ulcer Stomach Ulcer - drug therapy Stomach Ulcer - pathology Ulcers |
| title | Semipurified Ethyl Acetate Partition of Methanolic Extract of Melastoma malabathricum Leaves Exerts Gastroprotective Activity Partly via Its Antioxidant-Antisecretory-Anti-Inflammatory Action and Synergistic Action of Several Flavonoid-Based Compounds |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T06%3A44%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Semipurified%20Ethyl%20Acetate%20Partition%20of%20Methanolic%20Extract%20of%20Melastoma%20malabathricum%20Leaves%20Exerts%20Gastroprotective%20Activity%20Partly%20via%20Its%20Antioxidant-Antisecretory-Anti-Inflammatory%20Action%20and%20Synergistic%20Action%20of%20Several%20Flavonoid-Based%20Compounds&rft.jtitle=Oxidative%20medicine%20and%20cellular%20longevity&rft.au=Zakaria,%20Zainul%20Amiruddin&rft.date=2017-01-01&rft.volume=2017&rft.issue=2017&rft.spage=1&rft.epage=14&rft.pages=1-14&rft.issn=1942-0900&rft.eissn=1942-0994&rft_id=info:doi/10.1155/2017/6542631&rft_dat=%3Cgale_pubme%3EA555850696%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1860644826&rft_id=info:pmid/28168011&rft_galeid=A555850696&rfr_iscdi=true |