Decreased Expression of Hsa_circ_00001649 in Gastric Cancer and Its Clinical Significance

Decreased Expression of Hsa_circ_00001649 in Gastric Cancer and Its Clinical Significance

Background. It has been reported that circRNAs are differentially expressed in a wide range of cancers and could be used as a new biomarker for diagnosis. However, the correlation between circRNAs and gastric cancer (GC) it is still unclear. Materials and Methods. In this study, by using real-time q...

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Veröffentlicht in:Disease markers 2017-01, Vol.2017 (2017), p.1-6
Hauptverfasser: Chang, Dong-min, Xia, Peng, Guo, Kun, Zeng, Qingnuo, Xie, Xin, Zhou, Zhang-jian, Zhang, Hao, Song, Yong-chun, Li, Wen-han, Wang, Ying
Format: Artikel
Sprache:eng
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Adult
Aged
Biological markers
Biomarkers, Tumor - blood
Biomarkers, Tumor - metabolism
Cell Line, Tumor
Diagnosis
Down-Regulation
Female
Gene expression
Genetic aspects
Humans
Male
Middle Aged
RNA - blood
RNA - metabolism
Stomach cancer
Stomach Neoplasms - blood
Stomach Neoplasms - metabolism
Stomach Neoplasms - pathology
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Zusammenfassung:Background. It has been reported that circRNAs are differentially expressed in a wide range of cancers and could be used as a new biomarker for diagnosis. However, the correlation between circRNAs and gastric cancer (GC) it is still unclear. Materials and Methods. In this study, by using real-time quantitative reverse transcription-polymerase chain reactions (qRT-PCRs), we detected the expression level of hsa_circ_0001649 in tissue and serum samples from GC patients. Results. We found that hsa_circ_0001649 expression was significantly downregulated in GC tissue compared with their paired paracancerous histological normal tissues (PCHNTs) (P
ISSN:0278-0240
1875-8630
DOI:10.1155/2017/4587698