The Mechanism of Computed Tomography-Guided 125I Particle in Treating Lung Cancer
BACKGROUND The incidence of malignant tumor has gradually increased. How to improve the survival and quality of life of patients who lose the opportunity for surgery or who are unwilling to receive surgery remains an obstacle. At present, 125I particle interstitial implant therapy has been applied i...
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| Veröffentlicht in: | Medical science monitor 2017-01, Vol.23, p.292-299 |
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| description | BACKGROUND The incidence of malignant tumor has gradually increased. How to improve the survival and quality of life of patients who lose the opportunity for surgery or who are unwilling to receive surgery remains an obstacle. At present, 125I particle interstitial implant therapy has been applied in a variety of treatments of tumors. However, the mechanism of computed tomography (CT)-guided 125I particle therapy in lung cancer has not been fully elucidated. MATERIAL AND METHODS A total of 42 patients with advanced non-small cell lung cancer were retrospectively analyzed between January 2013 and December 2013, including 19 patients who received CT-guided 125I particle therapy and 23 patients who received chemotherapy. Curative effect and adverse reactions at 6 months and 12 months were compared and analyzed. A rabbit lung cancer VX2 model was treated by 125I particle implantation therapy under CT guidance. The change in tumor volume was detected. Tumor cell apoptosis was tested by flow cytometry. Bcl-2 and Bax expression were determined by real-time polymerase chain reaction (PCR) and Western blot. RESULTS 125I particle therapy obviously reduced tumor volume after 6 months and 12 months. It showed significantly higher efficiency (57.9%, 57.9%) and control (78.9%, 73.7%) than the rates of efficiency and control in the chemotherapy group (P |
| doi_str_mv | 10.12659/MSM.898526 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5266203</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1861572856</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2686-951215ce6608afeb69e807dff13582945b9d559f74cdb61febe51384da795dde3</originalsourceid><addsrcrecordid>eNpVkU1LAzEQhoMoWj9O3mWPgmzNR5NNLoIUrUKLivUc0mS2jexuarIr9N-7WJV6mRlmHt4Z5kXonOAhoYKr69nrbCiV5FTsoQERI5azguP9nfoIHaf0jjGVAvNDdEQlVpwpNkAv8xVkM7Ar0_hUZ6HMxqFedy24bB7qsIxmvdrkk867vkMof8yeTWy9rSDzTTaPYFrfLLNp14exaSzEU3RQmirB2U8-QW_3d_PxQz59mjyOb6e5pUKKXHFCCbcgBJamhIVQIHHhypIwLqka8YVynKuyGFm3EKQngBMmR84UijsH7ATdbHXX3aIGZ6Fpo6n0OvraxI0Oxuv_k8av9DJ86v5PgmLWC1z-CMTw0UFqde2ThaoyDYQuaSIF4QWVXPTo1Ra1MaQUofxbQ7D-NkH3JuitCT19sXvZH_v7dfYFunGCDw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1861572856</pqid></control><display><type>article</type><title>The Mechanism of Computed Tomography-Guided 125I Particle in Treating Lung Cancer</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Cheng, Jianzhong ; Ma, Shaozeng ; Yang, Guanghua ; Wang, Lisen ; Hou, Wei</creator><creatorcontrib>Cheng, Jianzhong ; Ma, Shaozeng ; Yang, Guanghua ; Wang, Lisen ; Hou, Wei</creatorcontrib><description>BACKGROUND The incidence of malignant tumor has gradually increased. How to improve the survival and quality of life of patients who lose the opportunity for surgery or who are unwilling to receive surgery remains an obstacle. At present, 125I particle interstitial implant therapy has been applied in a variety of treatments of tumors. However, the mechanism of computed tomography (CT)-guided 125I particle therapy in lung cancer has not been fully elucidated. MATERIAL AND METHODS A total of 42 patients with advanced non-small cell lung cancer were retrospectively analyzed between January 2013 and December 2013, including 19 patients who received CT-guided 125I particle therapy and 23 patients who received chemotherapy. Curative effect and adverse reactions at 6 months and 12 months were compared and analyzed. A rabbit lung cancer VX2 model was treated by 125I particle implantation therapy under CT guidance. The change in tumor volume was detected. Tumor cell apoptosis was tested by flow cytometry. Bcl-2 and Bax expression were determined by real-time polymerase chain reaction (PCR) and Western blot. RESULTS 125I particle therapy obviously reduced tumor volume after 6 months and 12 months. It showed significantly higher efficiency (57.9%, 57.9%) and control (78.9%, 73.7%) than the rates of efficiency and control in the chemotherapy group (P<0.05). 125I particle implantation therapy markedly suppressed rabbit VX2 transplanted tumor cell proliferation, promoted tumor regression, induced tumor cell apoptosis, reduced Bcl-2 expression, and upregulated Bax expression level (P<0.05). CONCLUSIONS CT-guided 125I particle implantation therapy can inhibit tumor proliferation and growth by regulating the expression of apoptosis-related genes and proteins, which is a promising approach in lung cancer treatment.</description><identifier>ISSN: 1643-3750</identifier><identifier>ISSN: 1234-1010</identifier><identifier>EISSN: 1643-3750</identifier><identifier>DOI: 10.12659/MSM.898526</identifier><identifier>PMID: 28095393</identifier><language>eng</language><publisher>United States: International Scientific Literature, Inc</publisher><subject>Adult ; Aged ; Animals ; Apoptosis ; bcl-2-Associated X Protein - genetics ; bcl-2-Associated X Protein - metabolism ; Carcinoma, Non-Small-Cell Lung - diagnostic imaging ; Carcinoma, Non-Small-Cell Lung - genetics ; Carcinoma, Non-Small-Cell Lung - pathology ; Clinical Research ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Iodine Radioisotopes ; Lung Neoplasms - diagnostic imaging ; Lung Neoplasms - genetics ; Lung Neoplasms - pathology ; Male ; Middle Aged ; Rabbits ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Survival Analysis ; Tomography, X-Ray Computed ; Tumor Burden</subject><ispartof>Medical science monitor, 2017-01, Vol.23, p.292-299</ispartof><rights>Med Sci Monit, 2017 2017</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2686-951215ce6608afeb69e807dff13582945b9d559f74cdb61febe51384da795dde3</citedby><cites>FETCH-LOGICAL-c2686-951215ce6608afeb69e807dff13582945b9d559f74cdb61febe51384da795dde3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266203/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266203/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28095393$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheng, Jianzhong</creatorcontrib><creatorcontrib>Ma, Shaozeng</creatorcontrib><creatorcontrib>Yang, Guanghua</creatorcontrib><creatorcontrib>Wang, Lisen</creatorcontrib><creatorcontrib>Hou, Wei</creatorcontrib><title>The Mechanism of Computed Tomography-Guided 125I Particle in Treating Lung Cancer</title><title>Medical science monitor</title><addtitle>Med Sci Monit</addtitle><description>BACKGROUND The incidence of malignant tumor has gradually increased. How to improve the survival and quality of life of patients who lose the opportunity for surgery or who are unwilling to receive surgery remains an obstacle. At present, 125I particle interstitial implant therapy has been applied in a variety of treatments of tumors. However, the mechanism of computed tomography (CT)-guided 125I particle therapy in lung cancer has not been fully elucidated. MATERIAL AND METHODS A total of 42 patients with advanced non-small cell lung cancer were retrospectively analyzed between January 2013 and December 2013, including 19 patients who received CT-guided 125I particle therapy and 23 patients who received chemotherapy. Curative effect and adverse reactions at 6 months and 12 months were compared and analyzed. A rabbit lung cancer VX2 model was treated by 125I particle implantation therapy under CT guidance. The change in tumor volume was detected. Tumor cell apoptosis was tested by flow cytometry. Bcl-2 and Bax expression were determined by real-time polymerase chain reaction (PCR) and Western blot. RESULTS 125I particle therapy obviously reduced tumor volume after 6 months and 12 months. It showed significantly higher efficiency (57.9%, 57.9%) and control (78.9%, 73.7%) than the rates of efficiency and control in the chemotherapy group (P<0.05). 125I particle implantation therapy markedly suppressed rabbit VX2 transplanted tumor cell proliferation, promoted tumor regression, induced tumor cell apoptosis, reduced Bcl-2 expression, and upregulated Bax expression level (P<0.05). CONCLUSIONS CT-guided 125I particle implantation therapy can inhibit tumor proliferation and growth by regulating the expression of apoptosis-related genes and proteins, which is a promising approach in lung cancer treatment.</description><subject>Adult</subject><subject>Aged</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>bcl-2-Associated X Protein - genetics</subject><subject>bcl-2-Associated X Protein - metabolism</subject><subject>Carcinoma, Non-Small-Cell Lung - diagnostic imaging</subject><subject>Carcinoma, Non-Small-Cell Lung - genetics</subject><subject>Carcinoma, Non-Small-Cell Lung - pathology</subject><subject>Clinical Research</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Iodine Radioisotopes</subject><subject>Lung Neoplasms - diagnostic imaging</subject><subject>Lung Neoplasms - genetics</subject><subject>Lung Neoplasms - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Rabbits</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Survival Analysis</subject><subject>Tomography, X-Ray Computed</subject><subject>Tumor Burden</subject><issn>1643-3750</issn><issn>1234-1010</issn><issn>1643-3750</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU1LAzEQhoMoWj9O3mWPgmzNR5NNLoIUrUKLivUc0mS2jexuarIr9N-7WJV6mRlmHt4Z5kXonOAhoYKr69nrbCiV5FTsoQERI5azguP9nfoIHaf0jjGVAvNDdEQlVpwpNkAv8xVkM7Ar0_hUZ6HMxqFedy24bB7qsIxmvdrkk867vkMof8yeTWy9rSDzTTaPYFrfLLNp14exaSzEU3RQmirB2U8-QW_3d_PxQz59mjyOb6e5pUKKXHFCCbcgBJamhIVQIHHhypIwLqka8YVynKuyGFm3EKQngBMmR84UijsH7ATdbHXX3aIGZ6Fpo6n0OvraxI0Oxuv_k8av9DJ86v5PgmLWC1z-CMTw0UFqde2ThaoyDYQuaSIF4QWVXPTo1Ra1MaQUofxbQ7D-NkH3JuitCT19sXvZH_v7dfYFunGCDw</recordid><startdate>20170117</startdate><enddate>20170117</enddate><creator>Cheng, Jianzhong</creator><creator>Ma, Shaozeng</creator><creator>Yang, Guanghua</creator><creator>Wang, Lisen</creator><creator>Hou, Wei</creator><general>International Scientific Literature, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170117</creationdate><title>The Mechanism of Computed Tomography-Guided 125I Particle in Treating Lung Cancer</title><author>Cheng, Jianzhong ; Ma, Shaozeng ; Yang, Guanghua ; Wang, Lisen ; Hou, Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2686-951215ce6608afeb69e807dff13582945b9d559f74cdb61febe51384da795dde3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>bcl-2-Associated X Protein - genetics</topic><topic>bcl-2-Associated X Protein - metabolism</topic><topic>Carcinoma, Non-Small-Cell Lung - diagnostic imaging</topic><topic>Carcinoma, Non-Small-Cell Lung - genetics</topic><topic>Carcinoma, Non-Small-Cell Lung - pathology</topic><topic>Clinical Research</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Iodine Radioisotopes</topic><topic>Lung Neoplasms - diagnostic imaging</topic><topic>Lung Neoplasms - genetics</topic><topic>Lung Neoplasms - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Rabbits</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Survival Analysis</topic><topic>Tomography, X-Ray Computed</topic><topic>Tumor Burden</topic><toplevel>online_resources</toplevel><creatorcontrib>Cheng, Jianzhong</creatorcontrib><creatorcontrib>Ma, Shaozeng</creatorcontrib><creatorcontrib>Yang, Guanghua</creatorcontrib><creatorcontrib>Wang, Lisen</creatorcontrib><creatorcontrib>Hou, Wei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medical science monitor</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, Jianzhong</au><au>Ma, Shaozeng</au><au>Yang, Guanghua</au><au>Wang, Lisen</au><au>Hou, Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Mechanism of Computed Tomography-Guided 125I Particle in Treating Lung Cancer</atitle><jtitle>Medical science monitor</jtitle><addtitle>Med Sci Monit</addtitle><date>2017-01-17</date><risdate>2017</risdate><volume>23</volume><spage>292</spage><epage>299</epage><pages>292-299</pages><issn>1643-3750</issn><issn>1234-1010</issn><eissn>1643-3750</eissn><abstract>BACKGROUND The incidence of malignant tumor has gradually increased. How to improve the survival and quality of life of patients who lose the opportunity for surgery or who are unwilling to receive surgery remains an obstacle. At present, 125I particle interstitial implant therapy has been applied in a variety of treatments of tumors. However, the mechanism of computed tomography (CT)-guided 125I particle therapy in lung cancer has not been fully elucidated. MATERIAL AND METHODS A total of 42 patients with advanced non-small cell lung cancer were retrospectively analyzed between January 2013 and December 2013, including 19 patients who received CT-guided 125I particle therapy and 23 patients who received chemotherapy. Curative effect and adverse reactions at 6 months and 12 months were compared and analyzed. A rabbit lung cancer VX2 model was treated by 125I particle implantation therapy under CT guidance. The change in tumor volume was detected. Tumor cell apoptosis was tested by flow cytometry. Bcl-2 and Bax expression were determined by real-time polymerase chain reaction (PCR) and Western blot. RESULTS 125I particle therapy obviously reduced tumor volume after 6 months and 12 months. It showed significantly higher efficiency (57.9%, 57.9%) and control (78.9%, 73.7%) than the rates of efficiency and control in the chemotherapy group (P<0.05). 125I particle implantation therapy markedly suppressed rabbit VX2 transplanted tumor cell proliferation, promoted tumor regression, induced tumor cell apoptosis, reduced Bcl-2 expression, and upregulated Bax expression level (P<0.05). CONCLUSIONS CT-guided 125I particle implantation therapy can inhibit tumor proliferation and growth by regulating the expression of apoptosis-related genes and proteins, which is a promising approach in lung cancer treatment.</abstract><cop>United States</cop><pub>International Scientific Literature, Inc</pub><pmid>28095393</pmid><doi>10.12659/MSM.898526</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Animals Apoptosis bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism Carcinoma, Non-Small-Cell Lung - diagnostic imaging Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Clinical Research Female Gene Expression Regulation, Neoplastic Humans Iodine Radioisotopes Lung Neoplasms - diagnostic imaging Lung Neoplasms - genetics Lung Neoplasms - pathology Male Middle Aged Rabbits RNA, Messenger - genetics RNA, Messenger - metabolism Survival Analysis Tomography, X-Ray Computed Tumor Burden |
| title | The Mechanism of Computed Tomography-Guided 125I Particle in Treating Lung Cancer |
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