Potential harmful correlation between homocysteine and low-density lipoprotein cholesterol in patients with hypothyroidism
Hypothyroidism (HO) can induce metabolic dysfunctions related to insulin resistance and dyslipidemia. Our previous studies showed that homocysteine (Hcy) impaired the coronary endothelial function and that Hcy can promote chemokine expression and insulin resistance (IR) by inducing endoplasmic retic...
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| Veröffentlicht in: | Medicine (Baltimore) 2016-07, Vol.95 (29), p.e4291-e4291 |
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| creator | Dong, Xuejie Yao, Zhi Hu, Yanjin Yang, Ning Gao, Xia Xu, Yuan Wang, Guang |
| description | Hypothyroidism (HO) can induce metabolic dysfunctions related to insulin resistance and dyslipidemia. Our previous studies showed that homocysteine (Hcy) impaired the coronary endothelial function and that Hcy can promote chemokine expression and insulin resistance (IR) by inducing endoplasmic reticulum stress in human adipose tissue and hypothyroid patients. The aim of this study was to investigate the potential harmful correlation between plasma Hcy and low-density lipoprotein cholesterol (LDL-C) in patients with HO.
A total of 286 subjects were enrolled. All subjects were divided into the following 3 groups: HO group, subclinical hypothyroidism (SHO) group, and control group. Statistical analyses were carried out to evaluate the correlation between the plasma levels of Hcy and LDL-C in HO patients. The changes in the plasma Hcy levels and other metabolic parameters were measured before and after levothyroxine (L-T4) treatment. The relationship between the changes in the plasma Hcy level and the LDL-C level was also evaluated after L-T4 treatment.
In the patients with HO, both the plasma Hcy and LDL-C levels were significantly higher than those of the controls. The plasma levels of Hcy were positively correlated with the LDL-C level in the HO group. L-T4 treatment resulted in a significant decrease in the BMI, total cholesterol (TC), LDL-C, triglycerides (TG), apolipoprotein B (ApoB), and Hcy levels. Moreover, the decrease in Hcy (ΔHcy) was positively correlated with decreased LDL-C (ΔLDL-C) levels after L-T4 treatment in HO patients.
Our results suggest that the increased Hcy level was positively correlated with the LDL-C in the HO group. A potential harmful interaction may exist between Hcy and LDL-C under the HO condition. In addition to reducing the plasma levels of Hcy, L-T4 treatment exerts beneficial effects on patients with HO by improving dyslipidemia, including a decrease in the LDL-C level. |
| doi_str_mv | 10.1097/MD.0000000000004291 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5265788</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1806439061</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4501-b429685e5969739e1da3a5d1cde2196d74684a0ebe271ecc16ccc6b404c6dc873</originalsourceid><addsrcrecordid>eNpdkdFv1SAUxonRuLvpX2BiePSlEyiF8mJiNnUmW_RBnwml51qUlgp0Tf3r5XrnMuWFkPOd3zkfH0IvKDmnRMnXN5fn5MHhTNFHaEebWlSNEvwx2hHCmkoqyU_QaUrfCaG1ZPwpOmGScyYk3aFfn0OGKTvj8WDiuF88tiFG8Ca7MOEO8gow4SGMwW4pg5sAm6nHPqxVD1NyecPezWGO4VDEdggeii4Gj8tzLpiCT3h1ecDDNoc8bDG43qXxGXqyNz7B87v7DH19_-7LxVV1_enDx4u315XlDaFVV4yJtoHiSclaAe1NbZqe2h4YVaKXXLTcEOiASQrWUmGtFR0n3IretrI-Q2-O3HnpRuht2Scar-foRhM3HYzT_1YmN-hv4VY3TDSybQvg1R0ghp9LcadHlyx4byYIS9K0JYLXighapPVRamNIKcL-fgwl-pCavrnU_6dWul4-3PC-529MRcCPgjX48rfph19WiHoA4_Pwh9dIxSpGqCCSKlIdyLT-DeEBp0M</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1806439061</pqid></control><display><type>article</type><title>Potential harmful correlation between homocysteine and low-density lipoprotein cholesterol in patients with hypothyroidism</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Wolters Kluwer Open Health</source><source>IngentaConnect Free/Open Access Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Dong, Xuejie ; Yao, Zhi ; Hu, Yanjin ; Yang, Ning ; Gao, Xia ; Xu, Yuan ; Wang, Guang</creator><creatorcontrib>Dong, Xuejie ; Yao, Zhi ; Hu, Yanjin ; Yang, Ning ; Gao, Xia ; Xu, Yuan ; Wang, Guang</creatorcontrib><description>Hypothyroidism (HO) can induce metabolic dysfunctions related to insulin resistance and dyslipidemia. Our previous studies showed that homocysteine (Hcy) impaired the coronary endothelial function and that Hcy can promote chemokine expression and insulin resistance (IR) by inducing endoplasmic reticulum stress in human adipose tissue and hypothyroid patients. The aim of this study was to investigate the potential harmful correlation between plasma Hcy and low-density lipoprotein cholesterol (LDL-C) in patients with HO.
A total of 286 subjects were enrolled. All subjects were divided into the following 3 groups: HO group, subclinical hypothyroidism (SHO) group, and control group. Statistical analyses were carried out to evaluate the correlation between the plasma levels of Hcy and LDL-C in HO patients. The changes in the plasma Hcy levels and other metabolic parameters were measured before and after levothyroxine (L-T4) treatment. The relationship between the changes in the plasma Hcy level and the LDL-C level was also evaluated after L-T4 treatment.
In the patients with HO, both the plasma Hcy and LDL-C levels were significantly higher than those of the controls. The plasma levels of Hcy were positively correlated with the LDL-C level in the HO group. L-T4 treatment resulted in a significant decrease in the BMI, total cholesterol (TC), LDL-C, triglycerides (TG), apolipoprotein B (ApoB), and Hcy levels. Moreover, the decrease in Hcy (ΔHcy) was positively correlated with decreased LDL-C (ΔLDL-C) levels after L-T4 treatment in HO patients.
Our results suggest that the increased Hcy level was positively correlated with the LDL-C in the HO group. A potential harmful interaction may exist between Hcy and LDL-C under the HO condition. In addition to reducing the plasma levels of Hcy, L-T4 treatment exerts beneficial effects on patients with HO by improving dyslipidemia, including a decrease in the LDL-C level.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000004291</identifier><identifier>PMID: 27442671</identifier><language>eng</language><publisher>United States: The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Adult ; Cholesterol, LDL - blood ; Clinical Trial/Experimental Study ; Cohort Studies ; Female ; Homocysteine - blood ; Humans ; Hypothyroidism - blood ; Hypothyroidism - drug therapy ; Male ; Middle Aged ; Reference Values ; Statistics as Topic ; Thyroid Function Tests ; Thyroxine - therapeutic use</subject><ispartof>Medicine (Baltimore), 2016-07, Vol.95 (29), p.e4291-e4291</ispartof><rights>The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.</rights><rights>Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4501-b429685e5969739e1da3a5d1cde2196d74684a0ebe271ecc16ccc6b404c6dc873</citedby><cites>FETCH-LOGICAL-c4501-b429685e5969739e1da3a5d1cde2196d74684a0ebe271ecc16ccc6b404c6dc873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5265788/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5265788/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27442671$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dong, Xuejie</creatorcontrib><creatorcontrib>Yao, Zhi</creatorcontrib><creatorcontrib>Hu, Yanjin</creatorcontrib><creatorcontrib>Yang, Ning</creatorcontrib><creatorcontrib>Gao, Xia</creatorcontrib><creatorcontrib>Xu, Yuan</creatorcontrib><creatorcontrib>Wang, Guang</creatorcontrib><title>Potential harmful correlation between homocysteine and low-density lipoprotein cholesterol in patients with hypothyroidism</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>Hypothyroidism (HO) can induce metabolic dysfunctions related to insulin resistance and dyslipidemia. Our previous studies showed that homocysteine (Hcy) impaired the coronary endothelial function and that Hcy can promote chemokine expression and insulin resistance (IR) by inducing endoplasmic reticulum stress in human adipose tissue and hypothyroid patients. The aim of this study was to investigate the potential harmful correlation between plasma Hcy and low-density lipoprotein cholesterol (LDL-C) in patients with HO.
A total of 286 subjects were enrolled. All subjects were divided into the following 3 groups: HO group, subclinical hypothyroidism (SHO) group, and control group. Statistical analyses were carried out to evaluate the correlation between the plasma levels of Hcy and LDL-C in HO patients. The changes in the plasma Hcy levels and other metabolic parameters were measured before and after levothyroxine (L-T4) treatment. The relationship between the changes in the plasma Hcy level and the LDL-C level was also evaluated after L-T4 treatment.
In the patients with HO, both the plasma Hcy and LDL-C levels were significantly higher than those of the controls. The plasma levels of Hcy were positively correlated with the LDL-C level in the HO group. L-T4 treatment resulted in a significant decrease in the BMI, total cholesterol (TC), LDL-C, triglycerides (TG), apolipoprotein B (ApoB), and Hcy levels. Moreover, the decrease in Hcy (ΔHcy) was positively correlated with decreased LDL-C (ΔLDL-C) levels after L-T4 treatment in HO patients.
Our results suggest that the increased Hcy level was positively correlated with the LDL-C in the HO group. A potential harmful interaction may exist between Hcy and LDL-C under the HO condition. In addition to reducing the plasma levels of Hcy, L-T4 treatment exerts beneficial effects on patients with HO by improving dyslipidemia, including a decrease in the LDL-C level.</description><subject>Adult</subject><subject>Cholesterol, LDL - blood</subject><subject>Clinical Trial/Experimental Study</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Homocysteine - blood</subject><subject>Humans</subject><subject>Hypothyroidism - blood</subject><subject>Hypothyroidism - drug therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Reference Values</subject><subject>Statistics as Topic</subject><subject>Thyroid Function Tests</subject><subject>Thyroxine - therapeutic use</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkdFv1SAUxonRuLvpX2BiePSlEyiF8mJiNnUmW_RBnwml51qUlgp0Tf3r5XrnMuWFkPOd3zkfH0IvKDmnRMnXN5fn5MHhTNFHaEebWlSNEvwx2hHCmkoqyU_QaUrfCaG1ZPwpOmGScyYk3aFfn0OGKTvj8WDiuF88tiFG8Ca7MOEO8gow4SGMwW4pg5sAm6nHPqxVD1NyecPezWGO4VDEdggeii4Gj8tzLpiCT3h1ecDDNoc8bDG43qXxGXqyNz7B87v7DH19_-7LxVV1_enDx4u315XlDaFVV4yJtoHiSclaAe1NbZqe2h4YVaKXXLTcEOiASQrWUmGtFR0n3IretrI-Q2-O3HnpRuht2Scar-foRhM3HYzT_1YmN-hv4VY3TDSybQvg1R0ghp9LcadHlyx4byYIS9K0JYLXighapPVRamNIKcL-fgwl-pCavrnU_6dWul4-3PC-529MRcCPgjX48rfph19WiHoA4_Pwh9dIxSpGqCCSKlIdyLT-DeEBp0M</recordid><startdate>20160701</startdate><enddate>20160701</enddate><creator>Dong, Xuejie</creator><creator>Yao, Zhi</creator><creator>Hu, Yanjin</creator><creator>Yang, Ning</creator><creator>Gao, Xia</creator><creator>Xu, Yuan</creator><creator>Wang, Guang</creator><general>The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved</general><general>Wolters Kluwer Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160701</creationdate><title>Potential harmful correlation between homocysteine and low-density lipoprotein cholesterol in patients with hypothyroidism</title><author>Dong, Xuejie ; Yao, Zhi ; Hu, Yanjin ; Yang, Ning ; Gao, Xia ; Xu, Yuan ; Wang, Guang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4501-b429685e5969739e1da3a5d1cde2196d74684a0ebe271ecc16ccc6b404c6dc873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Cholesterol, LDL - blood</topic><topic>Clinical Trial/Experimental Study</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Homocysteine - blood</topic><topic>Humans</topic><topic>Hypothyroidism - blood</topic><topic>Hypothyroidism - drug therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Reference Values</topic><topic>Statistics as Topic</topic><topic>Thyroid Function Tests</topic><topic>Thyroxine - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dong, Xuejie</creatorcontrib><creatorcontrib>Yao, Zhi</creatorcontrib><creatorcontrib>Hu, Yanjin</creatorcontrib><creatorcontrib>Yang, Ning</creatorcontrib><creatorcontrib>Gao, Xia</creatorcontrib><creatorcontrib>Xu, Yuan</creatorcontrib><creatorcontrib>Wang, Guang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dong, Xuejie</au><au>Yao, Zhi</au><au>Hu, Yanjin</au><au>Yang, Ning</au><au>Gao, Xia</au><au>Xu, Yuan</au><au>Wang, Guang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potential harmful correlation between homocysteine and low-density lipoprotein cholesterol in patients with hypothyroidism</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2016-07-01</date><risdate>2016</risdate><volume>95</volume><issue>29</issue><spage>e4291</spage><epage>e4291</epage><pages>e4291-e4291</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>Hypothyroidism (HO) can induce metabolic dysfunctions related to insulin resistance and dyslipidemia. Our previous studies showed that homocysteine (Hcy) impaired the coronary endothelial function and that Hcy can promote chemokine expression and insulin resistance (IR) by inducing endoplasmic reticulum stress in human adipose tissue and hypothyroid patients. The aim of this study was to investigate the potential harmful correlation between plasma Hcy and low-density lipoprotein cholesterol (LDL-C) in patients with HO.
A total of 286 subjects were enrolled. All subjects were divided into the following 3 groups: HO group, subclinical hypothyroidism (SHO) group, and control group. Statistical analyses were carried out to evaluate the correlation between the plasma levels of Hcy and LDL-C in HO patients. The changes in the plasma Hcy levels and other metabolic parameters were measured before and after levothyroxine (L-T4) treatment. The relationship between the changes in the plasma Hcy level and the LDL-C level was also evaluated after L-T4 treatment.
In the patients with HO, both the plasma Hcy and LDL-C levels were significantly higher than those of the controls. The plasma levels of Hcy were positively correlated with the LDL-C level in the HO group. L-T4 treatment resulted in a significant decrease in the BMI, total cholesterol (TC), LDL-C, triglycerides (TG), apolipoprotein B (ApoB), and Hcy levels. Moreover, the decrease in Hcy (ΔHcy) was positively correlated with decreased LDL-C (ΔLDL-C) levels after L-T4 treatment in HO patients.
Our results suggest that the increased Hcy level was positively correlated with the LDL-C in the HO group. A potential harmful interaction may exist between Hcy and LDL-C under the HO condition. In addition to reducing the plasma levels of Hcy, L-T4 treatment exerts beneficial effects on patients with HO by improving dyslipidemia, including a decrease in the LDL-C level.</abstract><cop>United States</cop><pub>The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>27442671</pmid><doi>10.1097/MD.0000000000004291</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wolters Kluwer Open Health; IngentaConnect Free/Open Access Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Cholesterol, LDL - blood Clinical Trial/Experimental Study Cohort Studies Female Homocysteine - blood Humans Hypothyroidism - blood Hypothyroidism - drug therapy Male Middle Aged Reference Values Statistics as Topic Thyroid Function Tests Thyroxine - therapeutic use |
| title | Potential harmful correlation between homocysteine and low-density lipoprotein cholesterol in patients with hypothyroidism |
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