Extended Transgene Expression From a Nonintegrating Adenoviral Vector Containing Retroviral Elements

We studied the effects of specific retroviral elements in a first-generation serotype 5 adenoviral (Ad5) vector, AdLTR2EF1α-hEPO. This vector contains 858 base pair (bp) [251-bp envelope sequence plus 607-bp long-terminal repeat (LTR)] from Moloney murine leukemia virus (MoMLV), upstream of the huma...

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Veröffentlicht in:	Molecular therapy 2008-06, Vol.16 (6), p.1089-1097
Hauptverfasser:	Zheng, Changyu, Vitolo, Joseph M, Zhang, Weitian, Mineshiba, Fumi, Chiorini, John A, Baum, Bruce J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenoviruses Animals Antibodies Cytomegalovirus Dentistry DNA methylation Erythropoietin - genetics Female Gene Expression Regulation Gene therapy Genetic Vectors Humans Leukemia Moloney murine leukemia virus - genetics Physiology Promoter Regions, Genetic Proteins Rats Rats, Wistar Retroviridae - genetics Submandibular Gland - metabolism Terminal Repeat Sequences Transgenes Vectors (Biology)
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