Parathyroid Hormone-Like Hormone is a Poor Prognosis Marker of Head and Neck Cancer and Promotes Cell Growth via RUNX2 Regulation

Parathyroid Hormone-Like Hormone (PTHLH) is an autocrine/paracrine ligand that is up-regulated in head and neck squamous cell carcinoma (HNSCC). However, the cellular function and regulatory mechanism in HNSCC remains obscure. We investigated the clinical significance of PTHLH in HNSCC patients, and...

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Veröffentlicht in:	Scientific reports 2017-01, Vol.7 (1), p.41131-41131, Article 41131
Hauptverfasser:	Chang, Wei-Min, Lin, Yuan-Feng, Su, Chia-Yi, Peng, Hsuan-Yu, Chang, Yu-Chan, Hsiao, Jenn-Ren, Chen, Chi-Long, Chang, Jang-Yang, Shieh, Yi-Shing, Hsiao, Michael, Shiah, Shine-Gwo
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 38/39 631/337/641/83 631/67/1536 631/80/83 64/60 96/95 Animals Autocrine signalling Biomarkers, Tumor - analysis Calcium Calcium (blood) Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - pathology Cbfa-1 protein Cell cycle Cell growth Cell Line Cell proliferation Core Binding Factor Alpha 1 Subunit - metabolism DNA microarrays Feedback Gene Expression Profiling Gene Expression Regulation Head & neck cancer Head and Neck Neoplasms - diagnosis Head and Neck Neoplasms - pathology Humanities and Social Sciences Humans Mice, SCID Microarray Analysis Models, Animal multidisciplinary Paracrine signalling Parathyroid Parathyroid hormone Parathyroid Hormone-Related Protein - metabolism Prognosis Rodents Science Science (multidisciplinary) Squamous cell carcinoma
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