Immunodominance of antibody recognition of the HIV envelope second variable region in immunoglobulin humanized mice

In the RV144 gp120 HIV vaccine trial, decreased transmission risk was correlated with antibodies that reacted with a linear epitope at a lysine at position 169 (K169) in the HIV-1 envelope (Env) second variable (V2) loop. The K169 V2 response was restricted to antibodies bearing Vλ rearrangements th...

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Veröffentlicht in:	The Journal of immunology (1950) 2016-12, Vol.198 (3), p.1047-1055
Hauptverfasser:	Wiehe, Kevin, Nicely, Nathan I., Lockwood, Bradley, Kuraoka, Masayuki, Anasti, Kara, Arora, Sabrina, Bowman, Cindy M., Stolarchuk, Christina, Parks, Robert, Lloyd, Krissey E., Xia, Shi-Mao, Duffy, Ryan, Shen, Xiaoying, Kyratsous, Christos A., Macdonald, Lynn E., Murphy, Andrew J., Scearce, Richard M., Moody, M. Anthony, Alam, S. Munir, Verkoczy, Laurent, Tomaras, Georgia D., Kelsoe, Garnett, Haynes, Barton F.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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