Failure to Achieve Normal Metabolic Response in Non-Obese Diabetic Mice and Streptozotocin-Induced Diabetic Mice After Transplantation of Primary Murine Hepatocytes Electroporated With the Human Proinsulin Gene (p3MTChins)

Abstract Background A recent study by Chen et al described a therapy for diabetes that involved electroporation of primary hepatocytes with human proinsulin cDNA, p3MTChins. Intrahepatic transplantation of treated hepatocytes into streptozotocin (STZ) murine and porcine models led to euglycemia, wei...

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Veröffentlicht in:	Transplantation proceedings 2014-07, Vol.46 (6), p.2002-2006
Hauptverfasser:	Lee, R.H, Roll, G, Nguyen, V, Willenbring, H, Tang, Q, Kang, S.-M, Stock, P.G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Glucose - metabolism C-Peptide - metabolism Diabetes Mellitus, Experimental - etiology Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - therapy DNA, Complementary - genetics Electroporation Gene Transfer Techniques Genetic Therapy Hepatocytes - transplantation Humans Insulin - metabolism Liver Male Mice Mice, Inbred NOD Proinsulin - genetics Spleen Streptozocin Surgery Swine
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