Pilot evaluation of a novel unilateral onychectomy model and efficacy of an extended release buprenorphine product
Non-steroidal anti-inflammatory drugs (NSAIDs), transdermal fentanyl patches, and transmucosal buprenorphine are probably the most commonly used options for providing post-operative analgesia in the early at-home period. However, these require daily administration or are associated with abuse concer...
Gespeichert in:
| Veröffentlicht in: | BMC veterinary research 2017-01, Vol.13 (1), p.32-32, Article 32 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 32 |
|---|---|
| container_issue | 1 |
| container_start_page | 32 |
| container_title | BMC veterinary research |
| container_volume | 13 |
| creator | Enomoto, Masataka Kigin, Patricia D Bledsoe, David Slone, Robyn Hash, Jonathan Smith, Charles E Lascelles, B Duncan X |
| description | Non-steroidal anti-inflammatory drugs (NSAIDs), transdermal fentanyl patches, and transmucosal buprenorphine are probably the most commonly used options for providing post-operative analgesia in the early at-home period. However, these require daily administration or are associated with abuse concerns. One of the significant unmet needs in veterinary surgery and pain management is for longer acting opioids for cats to effectively bridge the gap between the in-hospital and at-home recovery periods. A proof of concept study of an extended release formulation of buprenorphine HCL (ER-Bup) was conducted using objective kinetic measures and a unilateral onychectomy model. Using a blinded, randomized, two period crossover design, four cats were allocated to control (saline) or ER-Bup (0.6 mg/kg, subcutaneously [SC]) treatment groups. All animals underwent a unilateral forelimb onychectomy per period with a washout/recovery period in between. Observational pain scores and kinetic data (using a pressure sensitive walkway [PSW]) were collected prior to (baseline) and at intervals for 72 h following surgery. Symmetry indices were derived for kinetic variables (peak vertical force [PVF]; vertical impulse [VI]) of each forelimb for landing following a jump and for walking. A rescue analgesic protocol was in place. Effect of surgery and treatment were evaluated using a mixed model statistical approach.
No cats required rescue analgesics based on subjective pain score. ER-Bup had a positive influence on subjective pain scores during the 72 h postsurgery (p = 0.0473). PVF and VI of the operated limb were significantly decreased for both landing (p |
| doi_str_mv | 10.1186/s12917-017-0943-5 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5259973</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A480608627</galeid><sourcerecordid>A480608627</sourcerecordid><originalsourceid>FETCH-LOGICAL-c488t-b9999f8c0427863cfa6677c54b51e7028a2ebf74bf68fe8bc393873dec5dec553</originalsourceid><addsrcrecordid>eNqFUk1rFTEUHUSxtfoD3EjAjZvRZCafG6EUv6CgC12HTOamLyWTjMnMo-_fm-mrtboxcEjgnnu49-Q0zUuC3xIi-btCOkVEizco2rfsUXNKBOUtJ1Q-fvA-aZ6Vco0xpUrwp81JJ2u_7Nlpk7_5kBYEexNWs_gUUXLIoJj2ENAafTALZBNQige7A7uk6YCmNNaiiSMC57w19nDbFBHcLBBHGFGGAKYAGtY5Q0x53vkIaM5pXO3yvHniTCjw4u4-a358_PD94nN7-fXTl4vzy9ZSKZd2UPU4aTHthOS9dYZzISyjAyMgcCdNB4MTdHBcOpCD7VUvRT-CZRtYf9a8P-rO6zDBaCEudRM9Zz-ZfNDJeP13Jfqdvkp7zTqmlOirwJs7gZx-rlAWPfliIQQTIa1Fd7g6qnhXp_sftf4WkaxTnajU1_9Qr9OaY3ViY1HBmBDqD-vKBNA-ulRHtJuoPqcScyz5rRY5smxOpWRw99sRrLeI6GNENN5QI6I3W149tOW-43cm-l_CBrhs</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1864755779</pqid></control><display><type>article</type><title>Pilot evaluation of a novel unilateral onychectomy model and efficacy of an extended release buprenorphine product</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>SpringerLink Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><source>Springer Nature OA Free Journals</source><creator>Enomoto, Masataka ; Kigin, Patricia D ; Bledsoe, David ; Slone, Robyn ; Hash, Jonathan ; Smith, Charles E ; Lascelles, B Duncan X</creator><creatorcontrib>Enomoto, Masataka ; Kigin, Patricia D ; Bledsoe, David ; Slone, Robyn ; Hash, Jonathan ; Smith, Charles E ; Lascelles, B Duncan X</creatorcontrib><description><![CDATA[Non-steroidal anti-inflammatory drugs (NSAIDs), transdermal fentanyl patches, and transmucosal buprenorphine are probably the most commonly used options for providing post-operative analgesia in the early at-home period. However, these require daily administration or are associated with abuse concerns. One of the significant unmet needs in veterinary surgery and pain management is for longer acting opioids for cats to effectively bridge the gap between the in-hospital and at-home recovery periods. A proof of concept study of an extended release formulation of buprenorphine HCL (ER-Bup) was conducted using objective kinetic measures and a unilateral onychectomy model. Using a blinded, randomized, two period crossover design, four cats were allocated to control (saline) or ER-Bup (0.6 mg/kg, subcutaneously [SC]) treatment groups. All animals underwent a unilateral forelimb onychectomy per period with a washout/recovery period in between. Observational pain scores and kinetic data (using a pressure sensitive walkway [PSW]) were collected prior to (baseline) and at intervals for 72 h following surgery. Symmetry indices were derived for kinetic variables (peak vertical force [PVF]; vertical impulse [VI]) of each forelimb for landing following a jump and for walking. A rescue analgesic protocol was in place. Effect of surgery and treatment were evaluated using a mixed model statistical approach.
No cats required rescue analgesics based on subjective pain score. ER-Bup had a positive influence on subjective pain scores during the 72 h postsurgery (p = 0.0473). PVF and VI of the operated limb were significantly decreased for both landing (p < 0.0001 and p < 0.0001) and walking (p < 0.0001 and p < 0.0001 respectively) compared to control. ER-Bup resulted in significantly decreased asymmetry in limb use during landing (PVF, p < 0.0001; VI, p < 0.0001) and walking (PVF, p = 0.0002, VI, p < 0.0001). The novel use of data collected following a jump from an elevated platform appeared to provide all desired information and was easier to collect than walking data.
This study demonstrates that SC administration of ER-Bup may be an effective analgesic for a 72 h period postoperatively. Furthermore, landing onto a PSW from an elevated perch may be a useful and efficient way to assess analgesics in cats using a unilateral model of limb pain.]]></description><identifier>ISSN: 1746-6148</identifier><identifier>EISSN: 1746-6148</identifier><identifier>DOI: 10.1186/s12917-017-0943-5</identifier><identifier>PMID: 28118835</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Analgesia ; Analgesics, Opioid - administration & dosage ; Analgesics, Opioid - therapeutic use ; Animals ; asymmetry ; Buprenorphine ; Buprenorphine - administration & dosage ; Buprenorphine - therapeutic use ; Cats - surgery ; cross-over studies ; declawing ; Delayed-Action Preparations ; Dosage and administration ; Drug therapy ; Female ; fentanyl ; Hoof and Claw - surgery ; Male ; Motor Activity ; narcotics ; Orthopedic Procedures - veterinary ; pain ; Pain Measurement - methods ; Pain Measurement - veterinary ; Pain, Postoperative - drug therapy ; Pain, Postoperative - veterinary ; Pilot Projects ; statistical analysis ; statistical models ; Steroidal anti-inflammatory agents</subject><ispartof>BMC veterinary research, 2017-01, Vol.13 (1), p.32-32, Article 32</ispartof><rights>COPYRIGHT 2017 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2017</rights><rights>The Author(s). 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-b9999f8c0427863cfa6677c54b51e7028a2ebf74bf68fe8bc393873dec5dec553</citedby><cites>FETCH-LOGICAL-c488t-b9999f8c0427863cfa6677c54b51e7028a2ebf74bf68fe8bc393873dec5dec553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259973/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259973/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28118835$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Enomoto, Masataka</creatorcontrib><creatorcontrib>Kigin, Patricia D</creatorcontrib><creatorcontrib>Bledsoe, David</creatorcontrib><creatorcontrib>Slone, Robyn</creatorcontrib><creatorcontrib>Hash, Jonathan</creatorcontrib><creatorcontrib>Smith, Charles E</creatorcontrib><creatorcontrib>Lascelles, B Duncan X</creatorcontrib><title>Pilot evaluation of a novel unilateral onychectomy model and efficacy of an extended release buprenorphine product</title><title>BMC veterinary research</title><addtitle>BMC Vet Res</addtitle><description><![CDATA[Non-steroidal anti-inflammatory drugs (NSAIDs), transdermal fentanyl patches, and transmucosal buprenorphine are probably the most commonly used options for providing post-operative analgesia in the early at-home period. However, these require daily administration or are associated with abuse concerns. One of the significant unmet needs in veterinary surgery and pain management is for longer acting opioids for cats to effectively bridge the gap between the in-hospital and at-home recovery periods. A proof of concept study of an extended release formulation of buprenorphine HCL (ER-Bup) was conducted using objective kinetic measures and a unilateral onychectomy model. Using a blinded, randomized, two period crossover design, four cats were allocated to control (saline) or ER-Bup (0.6 mg/kg, subcutaneously [SC]) treatment groups. All animals underwent a unilateral forelimb onychectomy per period with a washout/recovery period in between. Observational pain scores and kinetic data (using a pressure sensitive walkway [PSW]) were collected prior to (baseline) and at intervals for 72 h following surgery. Symmetry indices were derived for kinetic variables (peak vertical force [PVF]; vertical impulse [VI]) of each forelimb for landing following a jump and for walking. A rescue analgesic protocol was in place. Effect of surgery and treatment were evaluated using a mixed model statistical approach.
No cats required rescue analgesics based on subjective pain score. ER-Bup had a positive influence on subjective pain scores during the 72 h postsurgery (p = 0.0473). PVF and VI of the operated limb were significantly decreased for both landing (p < 0.0001 and p < 0.0001) and walking (p < 0.0001 and p < 0.0001 respectively) compared to control. ER-Bup resulted in significantly decreased asymmetry in limb use during landing (PVF, p < 0.0001; VI, p < 0.0001) and walking (PVF, p = 0.0002, VI, p < 0.0001). The novel use of data collected following a jump from an elevated platform appeared to provide all desired information and was easier to collect than walking data.
This study demonstrates that SC administration of ER-Bup may be an effective analgesic for a 72 h period postoperatively. Furthermore, landing onto a PSW from an elevated perch may be a useful and efficient way to assess analgesics in cats using a unilateral model of limb pain.]]></description><subject>Analgesia</subject><subject>Analgesics, Opioid - administration & dosage</subject><subject>Analgesics, Opioid - therapeutic use</subject><subject>Animals</subject><subject>asymmetry</subject><subject>Buprenorphine</subject><subject>Buprenorphine - administration & dosage</subject><subject>Buprenorphine - therapeutic use</subject><subject>Cats - surgery</subject><subject>cross-over studies</subject><subject>declawing</subject><subject>Delayed-Action Preparations</subject><subject>Dosage and administration</subject><subject>Drug therapy</subject><subject>Female</subject><subject>fentanyl</subject><subject>Hoof and Claw - surgery</subject><subject>Male</subject><subject>Motor Activity</subject><subject>narcotics</subject><subject>Orthopedic Procedures - veterinary</subject><subject>pain</subject><subject>Pain Measurement - methods</subject><subject>Pain Measurement - veterinary</subject><subject>Pain, Postoperative - drug therapy</subject><subject>Pain, Postoperative - veterinary</subject><subject>Pilot Projects</subject><subject>statistical analysis</subject><subject>statistical models</subject><subject>Steroidal anti-inflammatory agents</subject><issn>1746-6148</issn><issn>1746-6148</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFUk1rFTEUHUSxtfoD3EjAjZvRZCafG6EUv6CgC12HTOamLyWTjMnMo-_fm-mrtboxcEjgnnu49-Q0zUuC3xIi-btCOkVEizco2rfsUXNKBOUtJ1Q-fvA-aZ6Vco0xpUrwp81JJ2u_7Nlpk7_5kBYEexNWs_gUUXLIoJj2ENAafTALZBNQige7A7uk6YCmNNaiiSMC57w19nDbFBHcLBBHGFGGAKYAGtY5Q0x53vkIaM5pXO3yvHniTCjw4u4-a358_PD94nN7-fXTl4vzy9ZSKZd2UPU4aTHthOS9dYZzISyjAyMgcCdNB4MTdHBcOpCD7VUvRT-CZRtYf9a8P-rO6zDBaCEudRM9Zz-ZfNDJeP13Jfqdvkp7zTqmlOirwJs7gZx-rlAWPfliIQQTIa1Fd7g6qnhXp_sftf4WkaxTnajU1_9Qr9OaY3ViY1HBmBDqD-vKBNA-ulRHtJuoPqcScyz5rRY5smxOpWRw99sRrLeI6GNENN5QI6I3W149tOW-43cm-l_CBrhs</recordid><startdate>20170124</startdate><enddate>20170124</enddate><creator>Enomoto, Masataka</creator><creator>Kigin, Patricia D</creator><creator>Bledsoe, David</creator><creator>Slone, Robyn</creator><creator>Hash, Jonathan</creator><creator>Smith, Charles E</creator><creator>Lascelles, B Duncan X</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20170124</creationdate><title>Pilot evaluation of a novel unilateral onychectomy model and efficacy of an extended release buprenorphine product</title><author>Enomoto, Masataka ; Kigin, Patricia D ; Bledsoe, David ; Slone, Robyn ; Hash, Jonathan ; Smith, Charles E ; Lascelles, B Duncan X</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-b9999f8c0427863cfa6677c54b51e7028a2ebf74bf68fe8bc393873dec5dec553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Analgesia</topic><topic>Analgesics, Opioid - administration & dosage</topic><topic>Analgesics, Opioid - therapeutic use</topic><topic>Animals</topic><topic>asymmetry</topic><topic>Buprenorphine</topic><topic>Buprenorphine - administration & dosage</topic><topic>Buprenorphine - therapeutic use</topic><topic>Cats - surgery</topic><topic>cross-over studies</topic><topic>declawing</topic><topic>Delayed-Action Preparations</topic><topic>Dosage and administration</topic><topic>Drug therapy</topic><topic>Female</topic><topic>fentanyl</topic><topic>Hoof and Claw - surgery</topic><topic>Male</topic><topic>Motor Activity</topic><topic>narcotics</topic><topic>Orthopedic Procedures - veterinary</topic><topic>pain</topic><topic>Pain Measurement - methods</topic><topic>Pain Measurement - veterinary</topic><topic>Pain, Postoperative - drug therapy</topic><topic>Pain, Postoperative - veterinary</topic><topic>Pilot Projects</topic><topic>statistical analysis</topic><topic>statistical models</topic><topic>Steroidal anti-inflammatory agents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Enomoto, Masataka</creatorcontrib><creatorcontrib>Kigin, Patricia D</creatorcontrib><creatorcontrib>Bledsoe, David</creatorcontrib><creatorcontrib>Slone, Robyn</creatorcontrib><creatorcontrib>Hash, Jonathan</creatorcontrib><creatorcontrib>Smith, Charles E</creatorcontrib><creatorcontrib>Lascelles, B Duncan X</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC veterinary research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Enomoto, Masataka</au><au>Kigin, Patricia D</au><au>Bledsoe, David</au><au>Slone, Robyn</au><au>Hash, Jonathan</au><au>Smith, Charles E</au><au>Lascelles, B Duncan X</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pilot evaluation of a novel unilateral onychectomy model and efficacy of an extended release buprenorphine product</atitle><jtitle>BMC veterinary research</jtitle><addtitle>BMC Vet Res</addtitle><date>2017-01-24</date><risdate>2017</risdate><volume>13</volume><issue>1</issue><spage>32</spage><epage>32</epage><pages>32-32</pages><artnum>32</artnum><issn>1746-6148</issn><eissn>1746-6148</eissn><abstract><![CDATA[Non-steroidal anti-inflammatory drugs (NSAIDs), transdermal fentanyl patches, and transmucosal buprenorphine are probably the most commonly used options for providing post-operative analgesia in the early at-home period. However, these require daily administration or are associated with abuse concerns. One of the significant unmet needs in veterinary surgery and pain management is for longer acting opioids for cats to effectively bridge the gap between the in-hospital and at-home recovery periods. A proof of concept study of an extended release formulation of buprenorphine HCL (ER-Bup) was conducted using objective kinetic measures and a unilateral onychectomy model. Using a blinded, randomized, two period crossover design, four cats were allocated to control (saline) or ER-Bup (0.6 mg/kg, subcutaneously [SC]) treatment groups. All animals underwent a unilateral forelimb onychectomy per period with a washout/recovery period in between. Observational pain scores and kinetic data (using a pressure sensitive walkway [PSW]) were collected prior to (baseline) and at intervals for 72 h following surgery. Symmetry indices were derived for kinetic variables (peak vertical force [PVF]; vertical impulse [VI]) of each forelimb for landing following a jump and for walking. A rescue analgesic protocol was in place. Effect of surgery and treatment were evaluated using a mixed model statistical approach.
No cats required rescue analgesics based on subjective pain score. ER-Bup had a positive influence on subjective pain scores during the 72 h postsurgery (p = 0.0473). PVF and VI of the operated limb were significantly decreased for both landing (p < 0.0001 and p < 0.0001) and walking (p < 0.0001 and p < 0.0001 respectively) compared to control. ER-Bup resulted in significantly decreased asymmetry in limb use during landing (PVF, p < 0.0001; VI, p < 0.0001) and walking (PVF, p = 0.0002, VI, p < 0.0001). The novel use of data collected following a jump from an elevated platform appeared to provide all desired information and was easier to collect than walking data.
This study demonstrates that SC administration of ER-Bup may be an effective analgesic for a 72 h period postoperatively. Furthermore, landing onto a PSW from an elevated perch may be a useful and efficient way to assess analgesics in cats using a unilateral model of limb pain.]]></abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>28118835</pmid><doi>10.1186/s12917-017-0943-5</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1746-6148 |
| ispartof | BMC veterinary research, 2017-01, Vol.13 (1), p.32-32, Article 32 |
| issn | 1746-6148 1746-6148 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5259973 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; SpringerLink Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access; Springer Nature OA Free Journals |
| subjects | Analgesia Analgesics, Opioid - administration & dosage Analgesics, Opioid - therapeutic use Animals asymmetry Buprenorphine Buprenorphine - administration & dosage Buprenorphine - therapeutic use Cats - surgery cross-over studies declawing Delayed-Action Preparations Dosage and administration Drug therapy Female fentanyl Hoof and Claw - surgery Male Motor Activity narcotics Orthopedic Procedures - veterinary pain Pain Measurement - methods Pain Measurement - veterinary Pain, Postoperative - drug therapy Pain, Postoperative - veterinary Pilot Projects statistical analysis statistical models Steroidal anti-inflammatory agents |
| title | Pilot evaluation of a novel unilateral onychectomy model and efficacy of an extended release buprenorphine product |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-19T00%3A47%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pilot%20evaluation%20of%20a%20novel%20unilateral%20onychectomy%20model%20and%20efficacy%20of%20an%20extended%20release%20buprenorphine%20product&rft.jtitle=BMC%20veterinary%20research&rft.au=Enomoto,%20Masataka&rft.date=2017-01-24&rft.volume=13&rft.issue=1&rft.spage=32&rft.epage=32&rft.pages=32-32&rft.artnum=32&rft.issn=1746-6148&rft.eissn=1746-6148&rft_id=info:doi/10.1186/s12917-017-0943-5&rft_dat=%3Cgale_pubme%3EA480608627%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1864755779&rft_id=info:pmid/28118835&rft_galeid=A480608627&rfr_iscdi=true |