Adverse effects of microplastics and oxidative stress-induced MAPK/Nrf2 pathway-mediated defense mechanisms in the marine copepod Paracyclopina nana
Microplastic pollution causes a major concern in the marine environment due to their worldwide distribution, persistence, and adverse effects of these pollutants in the marine ecosystem. Despite its global presence, there is still a lack of information on the effect of microplastics on marine organi...
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| Veröffentlicht in: | Scientific reports 2017-01, Vol.7 (1), p.41323-41323, Article 41323 |
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| creator | Jeong, Chang-Bum Kang, Hye-Min Lee, Min-Chul Kim, Duck-Hyun Han, Jeonghoon Hwang, Dae-Sik Souissi, Sami Lee, Su-Jae Shin, Kyung-Hoon Park, Heum Gi Lee, Jae-Seong |
| description | Microplastic pollution causes a major concern in the marine environment due to their worldwide distribution, persistence, and adverse effects of these pollutants in the marine ecosystem. Despite its global presence, there is still a lack of information on the effect of microplastics on marine organisms at the molecular level. Herein we demonstrated ingestion and egestion of nano- (0.05 μm) and micro-sized (0.5 and 6 μm) polystyrene microbeads in the marine copepod
Paracyclopina nana
, and examined molecular responses to exposure to microbeads with
in vivo
endpoints such as growth rate and fecundity. Also, we proposed an adverse outcome pathway for microplastic exposure that covers molecular and individual levels. This study provides the first insight into the mode of action in terms of microplastic-induced oxidative stress and related signaling pathways in
P. nana
. |
| doi_str_mv | 10.1038/srep41323 |
| format | Article |
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Paracyclopina nana
, and examined molecular responses to exposure to microbeads with
in vivo
endpoints such as growth rate and fecundity. Also, we proposed an adverse outcome pathway for microplastic exposure that covers molecular and individual levels. This study provides the first insight into the mode of action in terms of microplastic-induced oxidative stress and related signaling pathways in
P. nana
.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep41323</identifier><identifier>PMID: 28117374</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>45/77 ; 631/158/2455 ; 704/172/4081 ; 704/829/826 ; 82/1 ; 82/80 ; 96/1 ; 96/95 ; Animals ; Antioxidants - metabolism ; Aquatic Organisms - metabolism ; Copepoda - drug effects ; Copepoda - enzymology ; Copepoda - metabolism ; Defense mechanisms ; Environmental Monitoring ; Fecundity ; Fluorescent Dyes - metabolism ; Glutathione Peroxidase - metabolism ; Glutathione Reductase - metabolism ; Glutathione Transferase - metabolism ; Growth rate ; Humanities and Social Sciences ; Ingestion ; MAP kinase ; Marine ecosystems ; Marine environment ; Marine organisms ; Marine pollution ; Microplastics ; Microspheres ; Mitogen-Activated Protein Kinases - metabolism ; Mode of action ; Models, Biological ; multidisciplinary ; NF-E2-Related Factor 2 - metabolism ; Oxidative stress ; Oxidative Stress - drug effects ; Phosphorylation - drug effects ; Plastic debris ; Plastic pollution ; Plastics - toxicity ; Pollutants ; Polystyrene ; Polystyrenes - chemistry ; Reactive Oxygen Species - metabolism ; Science ; Science (multidisciplinary) ; Side effects ; Signal Transduction - drug effects ; Superoxide Dismutase - metabolism</subject><ispartof>Scientific reports, 2017-01, Vol.7 (1), p.41323-41323, Article 41323</ispartof><rights>The Author(s) 2017</rights><rights>Copyright Nature Publishing Group Jan 2017</rights><rights>Copyright © 2017, The Author(s) 2017 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-7549f118c3970d2992d44c5d8a4c11f55f8e8a7806b3b387a92115e83bfd3ffa3</citedby><cites>FETCH-LOGICAL-c504t-7549f118c3970d2992d44c5d8a4c11f55f8e8a7806b3b387a92115e83bfd3ffa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259799/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259799/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28117374$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jeong, Chang-Bum</creatorcontrib><creatorcontrib>Kang, Hye-Min</creatorcontrib><creatorcontrib>Lee, Min-Chul</creatorcontrib><creatorcontrib>Kim, Duck-Hyun</creatorcontrib><creatorcontrib>Han, Jeonghoon</creatorcontrib><creatorcontrib>Hwang, Dae-Sik</creatorcontrib><creatorcontrib>Souissi, Sami</creatorcontrib><creatorcontrib>Lee, Su-Jae</creatorcontrib><creatorcontrib>Shin, Kyung-Hoon</creatorcontrib><creatorcontrib>Park, Heum Gi</creatorcontrib><creatorcontrib>Lee, Jae-Seong</creatorcontrib><title>Adverse effects of microplastics and oxidative stress-induced MAPK/Nrf2 pathway-mediated defense mechanisms in the marine copepod Paracyclopina nana</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Microplastic pollution causes a major concern in the marine environment due to their worldwide distribution, persistence, and adverse effects of these pollutants in the marine ecosystem. Despite its global presence, there is still a lack of information on the effect of microplastics on marine organisms at the molecular level. Herein we demonstrated ingestion and egestion of nano- (0.05 μm) and micro-sized (0.5 and 6 μm) polystyrene microbeads in the marine copepod
Paracyclopina nana
, and examined molecular responses to exposure to microbeads with
in vivo
endpoints such as growth rate and fecundity. Also, we proposed an adverse outcome pathway for microplastic exposure that covers molecular and individual levels. This study provides the first insight into the mode of action in terms of microplastic-induced oxidative stress and related signaling pathways in
P. nana
.</description><subject>45/77</subject><subject>631/158/2455</subject><subject>704/172/4081</subject><subject>704/829/826</subject><subject>82/1</subject><subject>82/80</subject><subject>96/1</subject><subject>96/95</subject><subject>Animals</subject><subject>Antioxidants - metabolism</subject><subject>Aquatic Organisms - metabolism</subject><subject>Copepoda - drug effects</subject><subject>Copepoda - enzymology</subject><subject>Copepoda - metabolism</subject><subject>Defense mechanisms</subject><subject>Environmental Monitoring</subject><subject>Fecundity</subject><subject>Fluorescent Dyes - metabolism</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Glutathione Reductase - metabolism</subject><subject>Glutathione Transferase - metabolism</subject><subject>Growth rate</subject><subject>Humanities and Social Sciences</subject><subject>Ingestion</subject><subject>MAP kinase</subject><subject>Marine ecosystems</subject><subject>Marine environment</subject><subject>Marine organisms</subject><subject>Marine pollution</subject><subject>Microplastics</subject><subject>Microspheres</subject><subject>Mitogen-Activated Protein Kinases - 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metabolism</topic><topic>Aquatic Organisms - metabolism</topic><topic>Copepoda - drug effects</topic><topic>Copepoda - enzymology</topic><topic>Copepoda - metabolism</topic><topic>Defense mechanisms</topic><topic>Environmental Monitoring</topic><topic>Fecundity</topic><topic>Fluorescent Dyes - metabolism</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>Glutathione Reductase - metabolism</topic><topic>Glutathione Transferase - metabolism</topic><topic>Growth rate</topic><topic>Humanities and Social Sciences</topic><topic>Ingestion</topic><topic>MAP kinase</topic><topic>Marine ecosystems</topic><topic>Marine environment</topic><topic>Marine organisms</topic><topic>Marine pollution</topic><topic>Microplastics</topic><topic>Microspheres</topic><topic>Mitogen-Activated Protein Kinases - metabolism</topic><topic>Mode of action</topic><topic>Models, Biological</topic><topic>multidisciplinary</topic><topic>NF-E2-Related Factor 2 - metabolism</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Phosphorylation - drug effects</topic><topic>Plastic debris</topic><topic>Plastic pollution</topic><topic>Plastics - toxicity</topic><topic>Pollutants</topic><topic>Polystyrene</topic><topic>Polystyrenes - chemistry</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Side effects</topic><topic>Signal Transduction - drug effects</topic><topic>Superoxide Dismutase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jeong, Chang-Bum</creatorcontrib><creatorcontrib>Kang, Hye-Min</creatorcontrib><creatorcontrib>Lee, Min-Chul</creatorcontrib><creatorcontrib>Kim, Duck-Hyun</creatorcontrib><creatorcontrib>Han, Jeonghoon</creatorcontrib><creatorcontrib>Hwang, Dae-Sik</creatorcontrib><creatorcontrib>Souissi, Sami</creatorcontrib><creatorcontrib>Lee, Su-Jae</creatorcontrib><creatorcontrib>Shin, Kyung-Hoon</creatorcontrib><creatorcontrib>Park, Heum Gi</creatorcontrib><creatorcontrib>Lee, Jae-Seong</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jeong, Chang-Bum</au><au>Kang, Hye-Min</au><au>Lee, Min-Chul</au><au>Kim, Duck-Hyun</au><au>Han, Jeonghoon</au><au>Hwang, Dae-Sik</au><au>Souissi, Sami</au><au>Lee, Su-Jae</au><au>Shin, Kyung-Hoon</au><au>Park, Heum Gi</au><au>Lee, Jae-Seong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adverse effects of microplastics and oxidative stress-induced MAPK/Nrf2 pathway-mediated defense mechanisms in the marine copepod Paracyclopina nana</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2017-01-24</date><risdate>2017</risdate><volume>7</volume><issue>1</issue><spage>41323</spage><epage>41323</epage><pages>41323-41323</pages><artnum>41323</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Microplastic pollution causes a major concern in the marine environment due to their worldwide distribution, persistence, and adverse effects of these pollutants in the marine ecosystem. Despite its global presence, there is still a lack of information on the effect of microplastics on marine organisms at the molecular level. Herein we demonstrated ingestion and egestion of nano- (0.05 μm) and micro-sized (0.5 and 6 μm) polystyrene microbeads in the marine copepod
Paracyclopina nana
, and examined molecular responses to exposure to microbeads with
in vivo
endpoints such as growth rate and fecundity. Also, we proposed an adverse outcome pathway for microplastic exposure that covers molecular and individual levels. This study provides the first insight into the mode of action in terms of microplastic-induced oxidative stress and related signaling pathways in
P. nana
.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28117374</pmid><doi>10.1038/srep41323</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 45/77 631/158/2455 704/172/4081 704/829/826 82/1 82/80 96/1 96/95 Animals Antioxidants - metabolism Aquatic Organisms - metabolism Copepoda - drug effects Copepoda - enzymology Copepoda - metabolism Defense mechanisms Environmental Monitoring Fecundity Fluorescent Dyes - metabolism Glutathione Peroxidase - metabolism Glutathione Reductase - metabolism Glutathione Transferase - metabolism Growth rate Humanities and Social Sciences Ingestion MAP kinase Marine ecosystems Marine environment Marine organisms Marine pollution Microplastics Microspheres Mitogen-Activated Protein Kinases - metabolism Mode of action Models, Biological multidisciplinary NF-E2-Related Factor 2 - metabolism Oxidative stress Oxidative Stress - drug effects Phosphorylation - drug effects Plastic debris Plastic pollution Plastics - toxicity Pollutants Polystyrene Polystyrenes - chemistry Reactive Oxygen Species - metabolism Science Science (multidisciplinary) Side effects Signal Transduction - drug effects Superoxide Dismutase - metabolism |
| title | Adverse effects of microplastics and oxidative stress-induced MAPK/Nrf2 pathway-mediated defense mechanisms in the marine copepod Paracyclopina nana |
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