NLRP3 inflammasome: Pathogenic role and potential therapeutic target for IgA nephropathy

We have previously showed that IL-1β is involved in the pathogenesis of both spontaneously occurring and passively induced IgA nephropathy (IgAN) models. However, the exact causal-relationship between NLRP3 inflammasome and the pathogenesis of IgAN remains unknown. In the present study, we showed th...

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Veröffentlicht in:	Scientific reports 2017-01, Vol.7 (1), p.41123-41123, Article 41123
Hauptverfasser:	Tsai, Yu-Ling, Hua, Kuo-Feng, Chen, Ann, Wei, Chyou-Wei, Chen, Wen-Shiang, Wu, Cheng-Yeu, Chu, Ching-Liang, Yu, Yung-Luen, Lo, Chia-Wen, Ka, Shuk-Man
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/21 13/31 42 42/89 631/154 631/443/272 64/60 82/51 Animal models Animals Antigen-antibody complexes Bone marrow Cell activation Dendritic cells Female Glomerulonephritis, IGA - immunology Glomerulonephritis, IGA - metabolism Humanities and Social Sciences IgA nephropathy IL-1β Immunoglobulin A Inflammasomes Inflammasomes - metabolism Kidney - immunology Kidney - metabolism Kidneys Lymphocytes T Macrophages Macrophages - metabolism Mice Mitochondria Mitochondria - metabolism multidisciplinary NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Pathogenesis Reactive Oxygen Species - metabolism Renal function Rodents Science Science (multidisciplinary)
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