A potential inhibitory function of draxin in regulating mouse trunk neural crest migration
Draxin is a repulsive axon guidance protein that plays important roles in the formation of three commissures in the central nervous system and dorsal interneuron 3 (dI3) in the chick spinal cord. In the present study, we report the expression pattern of mouse draxin in the embryonic mouse trunk spin...
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| Veröffentlicht in: | In vitro cellular & developmental biology. Animal 2017-01, Vol.53 (1), p.43-53 |
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| creator | Zhang, Sanbing Su, Yuhong Gao, Jinbao Zhang, Chenbing Tanaka, Hideaki |
| description | Draxin is a repulsive axon guidance protein that plays important roles in the formation of three commissures in the central nervous system and dorsal interneuron 3 (dI3) in the chick spinal cord. In the present study, we report the expression pattern of mouse draxin in the embryonic mouse trunk spinal cord. In the presence of draxin, the longest net migration length of a migrating mouse trunk neural crest cell was significantly reduced. In addition, the relative number of apolar neural crest cells increased as the draxin treatment time increased. Draxin caused actin cytoskeleton rearrangement in the migrating trunk neural crest cells. Our data suggest that draxin may regulate mouse trunk neural crest cell migration by the rearrangement of cell actin cytoskeleton and by reducing the polarization activity of these cells subsequently. |
| doi_str_mv | 10.1007/s11626-016-0079-0 |
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In the present study, we report the expression pattern of mouse draxin in the embryonic mouse trunk spinal cord. In the presence of draxin, the longest net migration length of a migrating mouse trunk neural crest cell was significantly reduced. In addition, the relative number of apolar neural crest cells increased as the draxin treatment time increased. Draxin caused actin cytoskeleton rearrangement in the migrating trunk neural crest cells. Our data suggest that draxin may regulate mouse trunk neural crest cell migration by the rearrangement of cell actin cytoskeleton and by reducing the polarization activity of these cells subsequently.</description><identifier>ISSN: 1071-2690</identifier><identifier>EISSN: 1543-706X</identifier><identifier>DOI: 10.1007/s11626-016-0079-0</identifier><identifier>PMID: 27649978</identifier><identifier>CODEN: IVCAED</identifier><language>eng</language><publisher>New York: Springer Science & Business Media LLC</publisher><subject>Actin Cytoskeleton - metabolism ; Animal Genetics and Genomics ; Animals ; Biomedical and Life Sciences ; CELL AND TISSUE MODELS ; Cell Biology ; Cell Culture ; Cell Movement ; Cell Polarity - drug effects ; Cercopithecus aethiops ; Chick Embryo ; chicks ; COS Cells ; Developmental Biology ; Gene Expression Regulation, Developmental ; in vitro studies ; Intercellular Signaling Peptides and Proteins - metabolism ; interneurons ; Life Sciences ; mice ; Mice, Knockout ; microfilaments ; neural crest ; Neural Crest - cytology ; Neural Crest - metabolism ; Neural Tube - cytology ; Recombinant Fusion Proteins - isolation & purification ; spinal cord ; Spinal Cord - metabolism ; Stem Cells ; Torso</subject><ispartof>In vitro cellular & developmental biology. Animal, 2017-01, Vol.53 (1), p.43-53</ispartof><rights>2017 Society for In Vitro Biology</rights><rights>The Author(s) 2016</rights><rights>Copyright Society for In Vitro Biology Jan 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c591t-a0da95eef50c1d3bb3d0f918ecebe42e8c7963bf147740e1bcfc9e4536b28b8c3</citedby><cites>FETCH-LOGICAL-c591t-a0da95eef50c1d3bb3d0f918ecebe42e8c7963bf147740e1bcfc9e4536b28b8c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/26575059$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/26575059$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,776,780,799,881,27903,27904,41467,42536,51298,57996,58229</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27649978$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Sanbing</creatorcontrib><creatorcontrib>Su, Yuhong</creatorcontrib><creatorcontrib>Gao, Jinbao</creatorcontrib><creatorcontrib>Zhang, Chenbing</creatorcontrib><creatorcontrib>Tanaka, Hideaki</creatorcontrib><title>A potential inhibitory function of draxin in regulating mouse trunk neural crest migration</title><title>In vitro cellular & developmental biology. Animal</title><addtitle>In Vitro Cell.Dev.Biol.-Animal</addtitle><addtitle>In Vitro Cell Dev Biol Anim</addtitle><description>Draxin is a repulsive axon guidance protein that plays important roles in the formation of three commissures in the central nervous system and dorsal interneuron 3 (dI3) in the chick spinal cord. In the present study, we report the expression pattern of mouse draxin in the embryonic mouse trunk spinal cord. In the presence of draxin, the longest net migration length of a migrating mouse trunk neural crest cell was significantly reduced. In addition, the relative number of apolar neural crest cells increased as the draxin treatment time increased. Draxin caused actin cytoskeleton rearrangement in the migrating trunk neural crest cells. Our data suggest that draxin may regulate mouse trunk neural crest cell migration by the rearrangement of cell actin cytoskeleton and by reducing the polarization activity of these cells subsequently.</description><subject>Actin Cytoskeleton - metabolism</subject><subject>Animal Genetics and Genomics</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>CELL AND TISSUE MODELS</subject><subject>Cell Biology</subject><subject>Cell Culture</subject><subject>Cell Movement</subject><subject>Cell Polarity - drug effects</subject><subject>Cercopithecus aethiops</subject><subject>Chick Embryo</subject><subject>chicks</subject><subject>COS Cells</subject><subject>Developmental Biology</subject><subject>Gene Expression Regulation, Developmental</subject><subject>in vitro studies</subject><subject>Intercellular Signaling Peptides and Proteins - metabolism</subject><subject>interneurons</subject><subject>Life Sciences</subject><subject>mice</subject><subject>Mice, Knockout</subject><subject>microfilaments</subject><subject>neural crest</subject><subject>Neural Crest - cytology</subject><subject>Neural Crest - metabolism</subject><subject>Neural Tube - cytology</subject><subject>Recombinant Fusion Proteins - isolation & purification</subject><subject>spinal cord</subject><subject>Spinal Cord - metabolism</subject><subject>Stem Cells</subject><subject>Torso</subject><issn>1071-2690</issn><issn>1543-706X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkk1rFTEUhgdRbK3-ABdKwE03o_mYfG2EUqwKBTcK4iYkmcw015nkmsyI_feey9RaXWggJHCe8-ac86ZpnhL8kmAsX1VCBBUtJrCx1C2-1xwT3rFWYvH5PtyxJC0VGh81j2rdYViaiIfNEZWi01qq4-bLGdrnJaQl2gnFdBVdXHK5RsOa_BJzQnlAfbE_YoIoKmFcJ7vENKI5rzWgpazpK0phLZDuS6gLmuNY7CH1cfNgsFMNT27Ok-bTxZuP5-_ayw9v35-fXbaea7K0FvdW8xAGjj3pmXOsx4MmKvjgQkeD8lIL5gbSSdnhQJwfvA4dZ8JR5ZRnJ83rTXe_ujn0HpqBasy-xNmWa5NtNH9GUrwyY_5uOOVKYQUCpzcCJX9boQczx-rDNNkUoEtDYW6cacnwf1GiOHBSKQ3oi7_QXV5LgkkAJTmjnHYCKLJRvuRaSxhu6ybYHEw2m8kGTDYHk82hiOd3G77N-OUqAHQDKoTSGMqdp_-h-mxL2lX4Ab9FBZccc81-AiNbvgo</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Zhang, Sanbing</creator><creator>Su, Yuhong</creator><creator>Gao, Jinbao</creator><creator>Zhang, Chenbing</creator><creator>Tanaka, Hideaki</creator><general>Springer Science & Business Media LLC</general><general>Springer US</general><general>Society for In Vitro Biology</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20170101</creationdate><title>A potential inhibitory function of draxin in regulating mouse trunk neural crest migration</title><author>Zhang, Sanbing ; Su, Yuhong ; Gao, Jinbao ; Zhang, Chenbing ; Tanaka, Hideaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c591t-a0da95eef50c1d3bb3d0f918ecebe42e8c7963bf147740e1bcfc9e4536b28b8c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Actin Cytoskeleton - 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Animal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Sanbing</au><au>Su, Yuhong</au><au>Gao, Jinbao</au><au>Zhang, Chenbing</au><au>Tanaka, Hideaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A potential inhibitory function of draxin in regulating mouse trunk neural crest migration</atitle><jtitle>In vitro cellular & developmental biology. Animal</jtitle><stitle>In Vitro Cell.Dev.Biol.-Animal</stitle><addtitle>In Vitro Cell Dev Biol Anim</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>53</volume><issue>1</issue><spage>43</spage><epage>53</epage><pages>43-53</pages><issn>1071-2690</issn><eissn>1543-706X</eissn><coden>IVCAED</coden><abstract>Draxin is a repulsive axon guidance protein that plays important roles in the formation of three commissures in the central nervous system and dorsal interneuron 3 (dI3) in the chick spinal cord. In the present study, we report the expression pattern of mouse draxin in the embryonic mouse trunk spinal cord. In the presence of draxin, the longest net migration length of a migrating mouse trunk neural crest cell was significantly reduced. In addition, the relative number of apolar neural crest cells increased as the draxin treatment time increased. Draxin caused actin cytoskeleton rearrangement in the migrating trunk neural crest cells. Our data suggest that draxin may regulate mouse trunk neural crest cell migration by the rearrangement of cell actin cytoskeleton and by reducing the polarization activity of these cells subsequently.</abstract><cop>New York</cop><pub>Springer Science & Business Media LLC</pub><pmid>27649978</pmid><doi>10.1007/s11626-016-0079-0</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Actin Cytoskeleton - metabolism Animal Genetics and Genomics Animals Biomedical and Life Sciences CELL AND TISSUE MODELS Cell Biology Cell Culture Cell Movement Cell Polarity - drug effects Cercopithecus aethiops Chick Embryo chicks COS Cells Developmental Biology Gene Expression Regulation, Developmental in vitro studies Intercellular Signaling Peptides and Proteins - metabolism interneurons Life Sciences mice Mice, Knockout microfilaments neural crest Neural Crest - cytology Neural Crest - metabolism Neural Tube - cytology Recombinant Fusion Proteins - isolation & purification spinal cord Spinal Cord - metabolism Stem Cells Torso |
| title | A potential inhibitory function of draxin in regulating mouse trunk neural crest migration |
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