PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPβ and Modulating Its Transcriptional Activity

Poly(ADP-ribosyl)ation (PARylation) is a post-translational modification of proteins mediated by PARP family members, such as PARP-1. Although PARylation has been studied extensively, few examples of definitive biological roles for site-specific PARylation have been reported. Here we show that C/EBP...

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Veröffentlicht in:	Molecular cell 2017-01, Vol.65 (2), p.260-271
Hauptverfasser:	Luo, Xin, Ryu, Keun Woo, Kim, Dae-Seok, Nandu, Tulip, Medina, Carlos J., Gupte, Rebecca, Gibson, Bryan A., Soccio, Raymond E., Yu, Yonghao, Gupta, Rana K., Kraus, W. Lee
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Adipocytes - drug effects Adipocytes - enzymology adipogenesis Adipogenesis - drug effects amino acids Animals Binding Sites C/EBPβ catalytic activity CCAAT-Enhancer-Binding Protein-beta - genetics CCAAT-Enhancer-Binding Protein-beta - metabolism DNA DNA - genetics DNA - metabolism DNA binding Embryonic Stem Cells - drug effects Embryonic Stem Cells - enzymology gene expression genes Genotype Male Mice Mice, Inbred C57BL Mice, Knockout Mutation NIH 3T3 Cells PARP inhibitor PARP-1 PARylation Phenotype Poly (ADP-Ribose) Polymerase-1 - antagonists & inhibitors Poly (ADP-Ribose) Polymerase-1 - deficiency Poly (ADP-Ribose) Polymerase-1 - genetics Poly (ADP-Ribose) Polymerase-1 - metabolism Poly Adenosine Diphosphate Ribose - metabolism poly(ADP-ribose) Poly(ADP-ribose) Polymerase Inhibitors - pharmacology post-translational modification Protein Binding Protein Domains Protein Processing, Post-Translational RNA Interference Signal Transduction Time Factors transcription transcription (genetics) transcription factors Transcription, Genetic - drug effects Transcriptional Activation Transfection
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