Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules

Resistance to chemotherapy represents a major obstacle for long-term remission, and effective strategies to overcome drug resistance would have significant clinical impact. We report that recurrent ovarian carcinomas after paclitaxel/carboplatin treatment have higher levels of spleen tyrosine kinase...

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Veröffentlicht in:	Cancer cell 2015-07, Vol.28 (1), p.82-96
Hauptverfasser:	Yu, Yu, Gaillard, Stephanie, Phillip, Jude M., Huang, Tai-Chung, Pinto, Sneha M., Tessarollo, Nayara G., Zhang, Zhen, Pandey, Akhilesh, Wirtz, Denis, Ayhan, Ayse, Davidson, Ben, Wang, Tian-Li, Shih, Ie-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Drug Resistance, Neoplasm - drug effects Drug Synergism Female Gene Knockdown Techniques Humans Intracellular Signaling Peptides and Proteins - antagonists & inhibitors Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Microtubule-Associated Proteins - metabolism Microtubules - drug effects Ovarian Neoplasms - drug therapy Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Oxazines - administration & dosage Oxazines - pharmacology Paclitaxel - administration & dosage Paclitaxel - pharmacology Phosphorylation - drug effects Protein-Tyrosine Kinases - antagonists & inhibitors Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism Pyridines - administration & dosage Pyridines - pharmacology Syk Kinase Tubulin - metabolism Up-Regulation Xenograft Model Antitumor Assays
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