Tissue Penetration of a Novel Spectinamide Antibiotic for the Treatment of Tuberculosis

The in vivo biodistribution and pharmacokinetics of 1329, a novel spectinamide antibiotic with anti-tubercular activity, were studied during intravenous administration of an tritium-labeled compound for nine consecutive, 12-hourly doses to rats. Serial blood samples were collected after the first an...

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Veröffentlicht in:	The AAPS journal 2016-05, Vol.18 (3), p.788-791
Hauptverfasser:	Madhura, Dora Babu, Trivedi, Ashit, Liu, Jiuyu, Boyd, Vincent A., Jeffries, Cynthia, Loveless, Vivian, Lee, Richard E., Meibohm, Bernd
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacology Biochemistry Biomedical and Life Sciences Biomedicine Biotechnology Brief/Technical Note Cell Line Male Mice Pharmacology/Toxicology Pharmacy Rats Rats, Sprague-Dawley Spectinomycin - analogs & derivatives Spectinomycin - metabolism Spectinomycin - pharmacology Tissue Distribution - drug effects Tissue Distribution - physiology Treatment Outcome Tuberculosis
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