Aggregation Kinetics for IgG1-Based Monoclonal Antibody Therapeutics

Monoclonal antibodies (mAbs) as a class of therapeutic molecules are finding an increasing demand in the biotechnology industry for the treatment of diseases like cancer and multiple sclerosis. A key challenge associated to successful commercialization of mAbs is that from the various physical and c...

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Veröffentlicht in:	The AAPS journal 2016-05, Vol.18 (3), p.689-702
Hauptverfasser:	Singla, A., Bansal, R., Joshi, Varsha, Rathore, Anurag S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - pharmacokinetics Biochemistry Biomedical and Life Sciences Biomedicine Biotechnology Chemistry, Pharmaceutical - methods Humans Immunoglobulin G - chemistry Immunoglobulin G - metabolism Kinetics Pharmacology/Toxicology Pharmacy Protein Aggregates - physiology Research Article
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