Variability in local action potential durations, dispersion of repolarization and wavelength restitution in aged wild-type and Scn5a^＋/- mouse hearts modeling human Brugada syndrome
Brugada syndrome is a primary arrhythmia syndrome characterized by loss-of-function mutations in the SCN5A gene, which encodes for the cardiac Na^＋ channel. In affected individuals, the risk of developing malignant ventricular arrhythmias and sudden cardiac death are increased.
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| Veröffentlicht in: | Journal of geriatric cardiology : JGC 2016-11, Vol.13 (11), p.930-931 |
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| container_issue | 11 |
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| container_title | Journal of geriatric cardiology : JGC |
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| creator | Tse, Gary Wong, Sheung Ting Tse, Vivian Yeo, Jie Ming |
| description | Brugada syndrome is a primary arrhythmia syndrome characterized by loss-of-function mutations in the SCN5A gene, which encodes for the cardiac Na^＋ channel. In affected individuals, the risk of developing malignant ventricular arrhythmias and sudden cardiac death are increased. |
| doi_str_mv | 10.11909/j.issn.1671-5411.2016.11.009 |
| format | Article |
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| subjects | Letter To The Editor 动作电位 心脏 时程 波长 离散度 综合征 老年 野生型 |
| title | Variability in local action potential durations, dispersion of repolarization and wavelength restitution in aged wild-type and Scn5a^＋/- mouse hearts modeling human Brugada syndrome |
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