Sensitivity of osteosarcoma cells to HDAC inhibitor AR-42 mediated apoptosis

Osteosarcoma (OS) is the most common primary bone tumor in both humans and dogs and is the second leading cause of cancer related deaths in children and young adults. Limb sparing surgery along with chemotherapy has been the mainstay of treatment for OS. Many patients are not cured with current ther...

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Veröffentlicht in:	BMC cancer 2017-01, Vol.17 (1), p.67-67, Article 67
Hauptverfasser:	Murahari, Sridhar, Jalkanen, Aimee L, Kulp, Samuel K, Chen, Ching-Shih, Modiano, Jaime F, London, Cheryl A, Kisseberth, William C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Apoptosis Bone cancer Bone Neoplasms - drug therapy Bone Neoplasms - metabolism Caspases - metabolism Cell cycle Cell death Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Chemotherapy Clinical trials Disease Dogs Dosage and administration Doxorubicin - pharmacology Drug Synergism Drug therapy FDA approval Gene Expression Regulation, Neoplastic - drug effects Histone Deacetylase Inhibitors - pharmacology Histones Humans Hydroxamic Acids - pharmacology Kinases Metastasis Multiple myeloma Osteosarcoma Osteosarcoma - drug therapy Osteosarcoma - metabolism Phenylbutyrates - pharmacology Phosphorylation Proto-Oncogene Proteins c-akt - metabolism Signal Transduction - drug effects Vorinostat
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